ArticleBulletin of experimental biology and medicine2025
Specific Features of the Chromosomal Composition of the Micronuclei in Women Living under Chronic Radiation Exposure.
Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Chromosomal composition of micronuclei of phytohemagglutinin-stimulated peripheral blood T lymphocytes in women chronically exposed to radiation due to their residence in the Techa riverside settlements in the Sothern Urals (mean age 76.4±1.2 years, mean cumulative dose for the red bone marrow 1.4±0.3 Gy) was analyzed using the cytochalasin-block micronucleus assay and multicolor fluorescent in situ hybridization (mFISH). Exposed women demonstrated an increase in the number of chromosomes eliminated from cell nucleus, but the frequency of micronuclei did not differ from that in the comparison group. High variability of the frequency of micronuclei was also noted in the group of exposed women. In all the women, X-chromosome and autosomes 2, 16 were significantly more often eliminated than other chromosomes.
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