ArticleBulletin of experimental biology and medicine2025
The Sensitivity of Opportunistic Bacteria to Blood Serum Low-Molecular Fraction Containing Antimicrobial Peptides and Proteins.
Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We studied the sensitivity of clinically significant (opportunistic) bacteria to blood serum fraction with a molecular weight <100 kDa containing antimicrobial peptides and proteins. The degree of damage to cytoplasmic membranes of bacterial cells was assessed by a spectrophotometric method. A total of 129 bacterial isolates belonging to 46 species, 19 genera, 13 families, 8 orders, 4 classes, and 3 types were studied. The mean sensitivity varied from -5.2 to 36.6%. The sensitivity depends on the structure of bacterial cell wall: higher sensitivity was demonstrated by taxonomic ranks related to gram-negative bacteria (median 19.1%) and lower values were observed in gram-positive bacteria (median 9.3%) (p<0.01). Among all orders, Lactobacilliales showed the lowest sensitivity (3.6%). Ranking of the studied species by their sensitivity showed that 7 of the first 15 species with sensitivity >19% are among to the leading causative agents of sepsis.
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