Evidence map›Paper›PMID 39945902›Full record

ArticleArchives of dermatological research2025

Bioinformatic analysis and experimental validation implicate STAT2-mediated angiogenic responses in rosacea pathogenesis.

Bancheng Chen, Chenchen Wu, Yan Liao, Hao Hu, Xiaojuan Liu, Chao Chen, Xiaoming Liu, Lin Wu, Xiaofan Chen, Bo Yu

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of dermatological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bancheng ChenDepartment of Dermatology, Peking University Shenzhen Hospital, Shenzhen, 518036, Guangdong Province, China.
Chenchen WuDepartment of Dermatology, Peking University Shenzhen Hospital, Shenzhen, 518036, Guangdong Province, China.
Yan LiaoDepartment of Dermatology, Peking University Shenzhen Hospital, Shenzhen, 518036, Guangdong Province, China.
Hao HuShenzhen Key Laboratory for Translational Medicine of Dermatology, Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, 518036, Guangdong Province, China.
Xiaojuan LiuShenzhen Key Laboratory for Translational Medicine of Dermatology, Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, 518036, Guangdong Province, China.
Chao ChenDepartment of Dermatology, Peking University Shenzhen Hospital, Shenzhen, 518036, Guangdong Province, China.
Xiaoming LiuDepartment of Dermatology, Peking University Shenzhen Hospital, Shenzhen, 518036, Guangdong Province, China.
Lin WuDepartment of Dermatology, Peking University Shenzhen Hospital, Shenzhen, 518036, Guangdong Province, China.
Xiaofan ChenShenzhen Key Laboratory for Translational Medicine of Dermatology, Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, 518036, Guangdong Province, China. littlecanva@163.com.
Bo YuDepartment of Dermatology, Peking University Shenzhen Hospital, Shenzhen, 518036, Guangdong Province, China. Drboyu_derm@126.com.

Funding

National Natural Science Foundation of China 82404134Sanming Project of Medicine in Shenzen Municipality SZSM202311029Shenzhen Key Medical Discipline Construction Fund SZXK040Shenzhen Science and Technology Program JCYJ20220530160207016Shenzhen Science and Technology Program JCYJ20240813162500001
6 · The paper itself

Abstract

Rosacea is a chronic skin condition characterized by facial erythema, flushing, and telangiectasia. Abnormalities in the vascular responses are associated with the development of rosacea. Our analysis of the GSE65914 dataset revealed differential expression of angiogenesis-related genes in rosacea lesions classified rosacea samples with distinct angiogenic molecular patterns. Further investigation of immune infiltration characteristics across angiogenic patterns identified unique immune signatures associated with VEGFA

Indexed as

Neovascularization, PathologicRosaceaSkinSTAT2 Transcription FactorAnimalsComputational BiologyDisease Models, AnimalFemaleGene Knockdown TechniquesHumansHuman Umbilical Vein Endothelial CellsMaleMiceVascular Endothelial Growth Factor ASTAT2 protein, humanSTAT2 Transcription FactorVascular Endothelial Growth Factor AVEGFA protein, humanAngiogenesisHUVECRosaceaSTAT2

Identifiers

PMID39945902

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.