Evidence map›Paper›PMID 39945857›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2025

The causal effect of natural killer cells on COVID-19 infection, hospitalization and severity.

Kaili Yang, Jun Quan, Zhi Liu, Zebing Huang, Shuyi Wang, Jia Li, Aiming Wang, Li Wu, Songman Yu, Panpan Yi and 4 more

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Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Kaili Yang *Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China.
Jun Quan *Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China.
Zhi LiuDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Zebing HuangDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China.
Shuyi WangDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China.
Jia LiDepartment of Emergency, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China.
Aiming WangDepartment of Emergency, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China.
Li WuDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China.
Songman YuDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China.
Panpan YiDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China.
Meifang XiaoDepartment of Health Management Center, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Yayu ChenDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China.
Xingwang HuDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China. lebithu@csu.edu.cn.
Shushan ZhaoDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, People's Republic of China. shushanzhao@csu.edu.cn.

Funding

Changsha Municipal Natural Science Foundation kq2208372National Natural Sciences Foundation of China 81970523National Natural Sciences Foundation of China 82300694National Natural Sciences Foundation of China 82370635Natural Sciences Foundation of hunan province 2021JJ70148Natural Sciences Foundation of hunan province 2022JJ70165Natural Sciences Foundation of hunan province 2023JJ30892
6 · The paper itself

Abstract

backgroundRecent studies have suggested that alterations in natural killer (NK) cell function may contribute to the development of COVID-19. Additionally, dysregulated NK cells may increase susceptibility to COVID-19 and affect the severity of the infection. PURPOSE: This study aimed to explore the causal relationship between NK cell-related immune traits and the risk of COVID-19 infection.

methodsA two-sample Mendelian randomization (MR) analysis was conducted to explore the causal relationship between NK cell-related immune traits and COVID-19. Exposure and outcome data were analyzed using the two-sample Mendelian Randomization (MR) method.

resultsThe results of the study suggest that there is a causal relationship between the absolute number of NK cells in COVID-19 infection and the risk of severe illness. The results also demonstrated that the morphological parameters are not causally related to COVID-19 infection but were causally related to COVID-19 hospitalization and COVID-19 severity.

conclusionThis finding has important implications for our understanding of the pathophysiology of COVID-19 and the development of future therapies and interventions for this disease.

Indexed as

COVID-19HospitalizationKiller Cells, NaturalHumansMendelian Randomization AnalysisSARS-CoV-2Severity of Illness IndexCausal relationshipCOVID-19Genome-wide association studyMendelian randomizationNK cell

Identifiers

PMID39945857

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.