Evidence map›Paper›PMID 39945822›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2026

Cholesterol metabolism and its implications in psychotic disorders: a comparative study of individuals at ultra high risk and control groups.

Mislene Bispo Teixeira Moreno, Monique Patricio Singulani, Martinus Theodorus van de Bilt, Alexandre Andrade Loch, Wagner Farid Gattaz, Leda Leme Talib

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mislene Bispo Teixeira MorenoLaboratory of Neuroscience, Department and Institute of Psychiatry, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), LIM-27)Rua Dr. Ovídio Pires de Campos, 785, São Paulo, SP-05403-010, Brazil.
Monique Patricio SingulaniLaboratory of Neuroscience, Department and Institute of Psychiatry, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), LIM-27)Rua Dr. Ovídio Pires de Campos, 785, São Paulo, SP-05403-010, Brazil.
Martinus Theodorus van de BiltLaboratory of Neuroscience, Department and Institute of Psychiatry, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), LIM-27)Rua Dr. Ovídio Pires de Campos, 785, São Paulo, SP-05403-010, Brazil.
Alexandre Andrade LochLaboratory of Neuroscience, Department and Institute of Psychiatry, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), LIM-27)Rua Dr. Ovídio Pires de Campos, 785, São Paulo, SP-05403-010, Brazil.
Wagner Farid GattazLaboratory of Neuroscience, Department and Institute of Psychiatry, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), LIM-27)Rua Dr. Ovídio Pires de Campos, 785, São Paulo, SP-05403-010, Brazil.
Leda Leme TalibLaboratory of Neuroscience, Department and Institute of Psychiatry, Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), LIM-27)Rua Dr. Ovídio Pires de Campos, 785, São Paulo, SP-05403-010, Brazil. leda.talib@hc.fm.usp.br.ORCID http://orcid.org/0000-0001-5866-1993

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 465412/2014-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2014/50873-3).
6 · The paper itself

Abstract

Psychotic disorders, particularly schizophrenia, are characterized by significant cognitive and social impairments, with early identification being crucial for effective intervention. Cholesterol plays a vital role in brain function and is primarily synthesized within the central nervous system. We analyzed plasma levels of total cholesterol and specific oxysterols, including 24-hydroxycholesterol, 27-hydroxycholesterol, and others, in a cohort of 61 ultra-high risk individuals and 44 healthy controls. Our findings indicate no difference in total cholesterol levels between groups; however, ultra-high risk individuals exhibited significantly increased levels of all measured oxysterols, suggesting dysregulation of cholesterol metabolism. Furthermore, a weak correlation was found between 27-hydroxycholesterol levels and positive psychotic symptoms. These results highlight the potential role of altered cholesterol metabolism in the early stages of psychotic disorders, proposing that specific oxysterols may serve as biomarkers for early detection and intervention strategies. This study contributes to the understanding of the biochemical underpinnings of psychosis and emphasizes the need for further investigation related to lipid metabolism and psychotic disorders.

Indexed as

CholesterolOxysterolsPsychotic DisordersAdultBiomarkersFemaleHumansMaleYoung AdultBiomarkersCholesterolOxysterolsBiomarkersCholesterolOxysterolsPsychotic disordersUltra-high-risk for psychosis

Identifiers

PMID39945822

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.