Evidence map›Paper›PMID 39945811›Full record

ArticleEuropean radiology2025

Comprehensive morphomechanical and wall enhancement analysis of intracranial aneurysms.

Sebastian Sanchez, Jacob M Miller, Adam Galloy, Marco Nino, Diego Ojeda, Elena Sagues, Carlos Dier, Andres Gudino, Rodrigo Jaramillo, Edgar A Samaniego

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Article in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sebastian SanchezDepartment of Neurology, Yale University, New Haven, CT, USA.
Jacob M MillerDepartment of Neurology, University of Iowa Health Care, Iowa City, IA, USA.
Adam GalloyRoy J Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA.
Marco NinoRoy J Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA.
Diego OjedaDepartment of Neurology, University of Connecticut, Hartford, CT, USA.
Elena SaguesDepartment of Neurology, University of Iowa Health Care, Iowa City, IA, USA.
Carlos DierDepartment of Neurology, University of Iowa Health Care, Iowa City, IA, USA.
Andres GudinoDepartment of Neurology, University of Iowa Health Care, Iowa City, IA, USA.
Rodrigo JaramilloDepartment of Neurology, University of Iowa Health Care, Iowa City, IA, USA.
Edgar A SamaniegoDepartment of Neurology, University of Iowa Health Care, Iowa City, IA, USA. edgarsama@gmail.com.ORCID http://orcid.org/0000-0002-0491-813X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionUnderstanding the relationship between aneurysm wall enhancement (AWE), wall shear stress (WSS), and wall tension (WT) across different brain aneurysm compartments may improve the assessment of rupture risk and vessel wall dynamics. Our comprehensive analysis aimed to evaluate these characteristics across different brain aneurysm compartments.

methodsPatients with intracranial aneurysms underwent 3-T high-resolution magnetic resonance imaging (MRI). T1-weighted images were obtained before and after administering gadolinium (Gd) contrast. 3D segmentations of the aneurysms were generated using 3D Slicer. AWE was quantified based on the signal intensity of the aneurysm wall on T1+Gd images. Finite element analysis calculated WT, while computational fluid dynamics assessed WSS metrics, including time-averaged wall shear stress (TAWSS), wall shear stress gradient (WSSG), and oscillatory shear index (OSI). AWE, WT, and WSS metrics were compared among aneurysms compartments and aneurysms stratified by size, aspect ratio (AR), and size ratio (SR).

resultsAWE was elevated in aneurysms with greater size and AR. WT and OSI were higher in aneurysms with larger sizes and higher AR and SR. Aneurysm necks exhibited higher WT, TAWSS, and WSSG compared to the aneurysm body. Irregular aneurysms displayed lower TAWSS, WSSG, and higher OSI in areas of high AWE. The bleb had the highest AWE and lowest WT and WSSG, while necks showed the lowest AWE and highest WT and WSSG.

conclusionAneurysm necks typically exhibit high WT and WSS, while the body often shows low WSS. Blebs express elevated AWE alongside diminished WSS and WT which potentially increases rupture risk KEY POINTS: Question Areas of high wall enhancement in irregular aneurysms are characterized by low wall sheer stress and high oscillatory sheer index. Findings High risk structures such as daughter sacs exhibit the highest wall enhancement and lowest wall sheer stress. Clinical relevance Comprehensive morphomechanical and wall enhancement analysis of brain aneurysms have the potential to offer valuable new insights into aneurysm biology.

Indexed as

Intracranial AneurysmMagnetic Resonance AngiographyMagnetic Resonance ImagingAdultAgedContrast MediaFemaleFinite Element AnalysisGadoliniumHumansImaging, Three-DimensionalMaleMiddle AgedStress, MechanicalContrast MediaGadoliniumBrain aneurysmComputational fluid dynamicsFinite element analysisVessel wall imagingWall enhancement.

Identifiers

PMID39945811

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.