ArticleSkeletal radiology2025
Calvarial melorheostosis: an extremely rare case and diagnostic challenge.
Article in Skeletal radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Melorheostosis: Clinical, radiological, and histopathological features with a literature review.Physiological reports · 2025Review
- Melorheostosis: A Rare Case Report with Pelvic and Lumbar Involvement.Journal of orthopaedic case reports · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melorheostosis is a rare bone disease that presents as sclerotic lesions growing on existing bone surfaces. This disease is of unknown etiology and affects both genders equally. The disease is unique in appearance, described in the literature as having a radiologic appearance of flowing candle wax, and usually occurs in the appendicular skeleton. We present an extremely rare case of melorheostosis of the calvarium in a 55-year-old male patient, initially thought to represent a large osteoma, and discuss the CT and MRI features, pathology, and surgical management. Recently, new insights have been gained by molecular biologic studies into the potential pathogenesis of this disease indicating genetic mutations, which will be discussed. This case report will help radiologists arriving at the correct diagnosis for an unusual manifestation of a rare disease.
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