Evidence map›Paper›PMID 39945738›Full record

ArticleThe journal of physical chemistry. B2025

Anion-Facilitated Hydrogen-Deuterium Exchange as a Tool to Probe Weak Anion-Protein Interactions Responsible for Hofmeister Effects.

Thien H Tran, Meghan Ricciardi, Lilly I Grunski, William C Wimley, Marcey L Waters, Bruce C Gibb

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Thien H TranDepartment of Chemistry, Tulane University School of Science and Engineering, New Orleans, Louisiana 70118, United States.ORCID 0009-0001-9359-5829
Meghan RicciardiDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.ORCID 0000-0003-3249-2241
Lilly I GrunskiDepartment of Chemistry, Tulane University School of Science and Engineering, New Orleans, Louisiana 70118, United States.
William C WimleyDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, Louisiana 70112, United States.ORCID 0000-0003-2967-5186
Marcey L WatersDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.ORCID 0000-0002-4917-5755
Bruce C GibbDepartment of Chemistry, Tulane University School of Science and Engineering, New Orleans, Louisiana 70118, United States.ORCID 0000-0002-4478-4084

Funding

NIH Administrative Supplement to Purchase a LyophilizerR35GM145227 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MARCEY L WATERS · 2022 to 2026
$2.2M
Ion-Ion Interactions and the Reverse Hofmeister EffectR01GM125690 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI GIBB, BRUCE C · 2018 to 2021
$1.7M
NIGMS NIH HHS R01 GM125690NIGMS NIH HHS R35 GM145227
6 · The paper itself

Abstract

Impeded by the complexity of proteinaceous structure and the very weak nature of the noncovalent interactions involved, the detailed mechanisms by which anions induce salting-in Hofmeister effects in proteins and peptides remain unclear. Here, using β-hairpin peptides as models, we examine two approaches to qualify (map) anion binding:

Indexed as

PeptidesProteinsAnionsDeuterium Exchange MeasurementHydrogenAnionsHydrogenPeptidesProteins

Identifiers

PMID39945738
PMCPMC11873968

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.