ArticleJACC. Clinical electrophysiology2025
Burden of Premature Ventricular Complexes and Risk of Cardiomyopathy: A Cross-Sectional Study.
Article in JACC. Clinical electrophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Clinical implications of intraoperative premature ventricular contractions for 30-day cardiovascular outcomes after liver transplantation.Journal of clinical monitoring and computing · 2026Article
- Association between systemic immune-inflammation index and ventricular premature contractions in patients without structural heart disease.Frontiers in cardiovascular medicine · 2026Article
- Speckle tracking technology and investigation of risk factors for premature ventricular contraction-induced cardiomyopathy.Frontiers in cardiovascular medicine · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundThe association between premature ventricular complexes (PVCs) and ventricular function has been described in several observational studies, where it has been implied that a higher burden of PVCs plays a causative role in reducing left ventricular ejection fraction (LVEF). To date, however, few studies have examined the association of PVCs and cardiomyopathy on a population level.
objectivesIn this treatment-agnostic, cross-sectional study, the authors examined the association of PVC burden with depressed LVEF.
methodsWe performed an analysis of >30,000 ambulatory monitors obtained on patients from April 22, 2017, and February 20, 2023. Subjects with ≥24 hours of monitoring, a PVC burden of ≥5%, and a transthoracic echocardiogram performed within 3 months of monitoring were included. The presence of cardiomyopathy was defined as LVEF <50%. Clinical factors including comorbidities and relevant medications were included and adjusted for.
resultsThe included sample included a total of 1,451 patients, with age 68.2 ± 14.5 years, female sex in 39.6%. The average PVC burden was 12.4% ± 7.4% (5%-43.4%). Of 746 subjects with a transthoracic echocardiogram, the mean LVEF was 55.6% ± 9.2% (25%-76.8%), with 171 subjects (22.9%) having an LVEF <50%. In both unadjusted and adjusted analyses, we found no significant association between percentage of PVCs and LVEF (P = 0.78), nor with PVC burden and depressed left ventricular function (P = 0.13).
conclusionsWe found no evidence that the PVC burden alone is an independent predictor of cardiomyopathy.
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