Evidence map›Paper›PMID 39945537›Full record

ArticleJournal of virology2025

Herpes simplex virus assembly and spread in murine skin after infection from the outside.

Timmy Richardo, Xiaokun Liu, Katinka Döhner, Tsung-Yu Chao, Anna Buch, Anne Binz, Anja Pohlmann, Madeleine de le Roi, Wolfgang Baumgärtner, Korbinian Brand and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Timmy RichardoInstitute of Virology, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-4927-2715
Xiaokun LiuInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Katinka DöhnerInstitute of Virology, Hannover Medical School, Hannover, Germany.
Tsung-Yu ChaoInstitute of Virology, Hannover Medical School, Hannover, Germany.
Anna BuchInstitute of Virology, Hannover Medical School, Hannover, Germany.
Anne BinzInstitute of Virology, Hannover Medical School, Hannover, Germany.
Anja PohlmannInstitute of Virology, Hannover Medical School, Hannover, Germany.
Madeleine de le RoiDepartment of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany.
Wolfgang BaumgärtnerDepartment of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany.
Korbinian BrandInstitute of Clinical Chemistry and Laboratory Medicine, Hannover Medical School, Hannover, Germany.
Rudolf BauerfeindResearch Core Unit Laser Microscopy, Hannover Medical School, Hannover, Germany.
Reinhold FörsterRESIST - Cluster of Excellence, Hannover Medical School, Hannover, Germany.
Beate SodeikInstitute of Virology, Hannover Medical School, Hannover, Germany.ORCID 0000-0003-4650-3036
Stephan HalleInstitute of Immunology, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-7624-7005

Funding

Deutsche Forschungsgemeinschaft (DFG) 158989968Deutsche Forschungsgemeinschaft (DFG) 390874280Deutsche Forschungsgemeinschaft (DFG) 398066876Deutscher Akademischer Austauschdienst (DAAD) 91727753
6 · The paper itself

Abstract

Herpes simplex viruses (HSV) cause many skin diseases, particularly in immunocompromised patients. HSV-1 infection of murine skin recapitulates many aspects of human pathology. However, many protocols rely on mechanical or enzymatic skin disruption to induce lesions, although this can alter skin homeostasis and prime antiviral inflammation before inoculation. To investigate the initial events following HSV-1 primary skin infection before the onset of symptoms, we developed a novel murine IMPORTANCE: This study describes a novel murine

Indexed as

Herpes SimplexHerpesvirus 1, HumanSkinVirus AssemblyAnimalsCapsidCapsid ProteinsChlorocebus aethiopsDisease Models, AnimalHumansKeratinocytesMiceCapsid ProteinsHSV-1HSV-1 pathogenesisskin infectionvirus spread

Identifiers

PMID39945537
PMCPMC11915863

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.