Evidence map›Paper›PMID 39945534›Full record

ArticleJournal of virology2025

Tracing more than two decades of Japanese encephalitis virus circulation in mainland China.

Gairu Li, Xinxin Li, Jie Chen, Phillipe Lemey, Bram Vrancken, Shuo Su, Simon Dellicour, Fabiana Gámbaro

Abstract read
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gairu LiJiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology, College of Veterinary Medicine, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Nanjing, China.
Xinxin LiJiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology, College of Veterinary Medicine, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Nanjing, China.
Jie ChenJiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology, College of Veterinary Medicine, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Nanjing, China.
Phillipe LemeyDepartment of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
Bram VranckenDepartment of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
Shuo Su *Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology, College of Veterinary Medicine, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Nanjing, China.ORCID 0000-0003-0187-1185
Simon Dellicour *Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.ORCID 0000-0001-9558-1052
Fabiana Gámbaro *Spatial Epidemiology Lab (SpELL), Université Libre de Bruxelles, Brussels, Belgium.ORCID 0000-0001-7760-2112

Funding

Technology CoreU19AI135995 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI Robert F Garry · 2018 to 2026
$32.0M
Fast and flexible Bayesian phylogenetics via modern machine learningR01AI162611 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MATSEN, FREDERICK ALBERT · 2021 to 2025
$3.8M
Statistical Innovation to Integrate Sequences and Phenotypes for Scalable Phylodynamic InferenceR01AI153044 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Marc A. Suchard · 2021 to 2026
$2.4M
EC | H2020 | PRIORITY 'Excellent science' | H2020 European Research Council (ERC) 725422EC | H2020 | PRIORITY 'Excellent science' | H2020 European Research Council (ERC) 874850Fonds De La Recherche Scientifique - FNRS (FNRS) F.4515.22Fonds Voor Wetenschappelijk Onderzoek - Vlaanderen G0D5117NFonds Voor Wetenschappelijk Onderzoek - Vlaanderen n{degree sign}G098321NFoundation of Jiangxi Educational Commission (The Natural Science Foundation of Jiangxi educational committee) BK20170721MOST | National Key Research and Development Program of China (NKPs) 2022YFC2604203NIAID NIH HHS R01 AI153044NIAID NIH HHS R01 AI162611NIAID NIH HHS U19 AI135995Sanya Yazhou Bay Science and Technology City (YZBSTC) SCKJ-JYRC-2022-08Wellcome TrustWellcome Trust (WT) 206298/Z/17/Z
6 · The paper itself

Abstract

Japanese encephalitis is a viral disease caused by the Japanese encephalitis virus (JEV), primarily affecting rural areas of Asia and western Pacific region. China remains one of the main epicenters, experiencing a significant burden of human and animal cases despite vaccination efforts. The ecology of this arbovirus is complex, involving IMPORTANCE: Japanese encephalitis virus (JEV) is the cause of Japanese encephalitis, a significant health concern in China. Despite being one of the most studied mosquito-borne viruses, no previous studies have combined genomic and geographic data to investigate the spatial epidemiology and dispersal capacity of the virus. In this study, we analyzed genomic, geographic, and environmental data to trace the dispersal history of JEV in China and explore the environmental factors influencing its distribution. Our findings show that JEV circulates predominantly in areas with higher temperatures, dense human and pig populations, and favorable conditions for

Indexed as

Encephalitis, JapaneseEncephalitis Virus, JapaneseAnimalsBirdsChinaCulexHumansMosquito VectorsPhylogenyPhylogeographySwineViral Envelope ProteinsViral Envelope Proteinsgenomic epidemiologyJapanese encephalitis virusphylogeography

Identifiers

PMID39945534
PMCPMC11915822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.