Evidence map›Paper›PMID 39945425›Full record

ArticleElectrophoresis2025

Surfactant-Based Polymer Microchip Electrophoresis of Ciprofloxacin Hydrochloride Monohydrate in Unfiltered Milk With Fluorescence Detection.

Camille A Leclerc, Christopher G D Ty, Sean S Worthington, Malley B Richardson, Abdulla K AlSawalhi, Larry Wood, Khalid Moomand, Christopher M Collier

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Electrophoresis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Camille A LeclercCollier Research Group, School of Engineering, The University of British Columbia, Kelowna, British Columbia, Canada.
Christopher G D TyCollier Research Group, School of Engineering, The University of British Columbia, Kelowna, British Columbia, Canada.
Sean S WorthingtonCollier Research Group, School of Engineering, The University of British Columbia, Kelowna, British Columbia, Canada.
Malley B RichardsonCollier Research Group, School of Engineering, The University of British Columbia, Kelowna, British Columbia, Canada.
Abdulla K AlSawalhiCollier Research Group, School of Engineering, The University of British Columbia, Kelowna, British Columbia, Canada.
Larry WoodCG Wellington, Drayton, Ontario, Canada.
Khalid MoomandAgrisan Specialty Chemical and Pharmaceutical, Arthur, Ontario, Canada.
Christopher M CollierCollier Research Group, School of Engineering, The University of British Columbia, Kelowna, British Columbia, Canada.

Funding

Natural Sciences and Engineering Research Council of Canada RGPIN-2023-04202NSERC Alliance ALLRP 570519-2021
6 · The paper itself

Abstract

This work describes a cross-shaped PMMA ME system capable of detecting ciprofloxacin hydrochloride monohydrate (CPFH) in unfiltered milk samples. The cross-shaped PMMA ME system utilizes a BGE consisting primarily of the surface-active agent SDS to solubilize milk fat and improve the zeta potential of the PMMA microchannel surface. A theoretical lumped-element circuit model for cross-shaped ME is introduced in this work to calculate the migration time of CPFH. This manuscript improves the capabilities of PMMA-based ME for CPFH in milk using an SDS-based BGE. The presented ME system has a faster migration time, higher mean output voltage, and thinner full-width at half-maximum than previously reported dairy-based biosensor systems. Most notably, the migration time of the new system is under 10 min, being the time associated with the milking of cattle. The system is also found to be able to detect the presence of milk fat. Discussion is included of potential future integration with existing high-sensitivity methodologies to place the overall ME system's limit of detection below an established target. To the authors' knowledge, this is the first reported account of a PMMA ME system capable of detecting CPFH in unfiltered milk.

Indexed as

CiprofloxacinElectrophoresis, MicrochipMilkSurface-Active AgentsAnimalsCattleLimit of DetectionPolymethyl MethacrylateCiprofloxacinPolymethyl MethacrylateSurface-Active Agentsantibiotic detectionmicrochip electrophoresismilkPMMA

Identifiers

PMID39945425
PMCPMC11865704

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.