Evidence map›Paper›PMID 39945293›Full record

ArticleACS biomaterials science & engineering2025

Microarc Oxidation Coatings Doped with a Low Proportion of Yttrium Enhance the Osseointegration of Titanium Implants through the BMP/Smad Pathway.

Chenyang Zhang, Chenghui Qian, Guang Yang, Yiying Zhu, Binbin Kang, Xiaohong Chen, Si Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS biomaterials science & engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chenyang ZhangDepartment of Oral Implantology, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai 200001, China.
Chenghui QianDepartment of Multidisciplinary Consultant Center, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai 200001, China.
Guang YangSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China.
Yiying ZhuDepartment of Oral Implantology, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai 200001, China.
Binbin KangSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China.
Xiaohong ChenSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China.
Si ChenDepartment of Multidisciplinary Consultant Center, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai 200001, China.ORCID 0000-0001-7652-145X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adding metal ions is a promising strategy to enhance the biological performance of titanium implants. In this study, we aimed to explore the effects of yttrium on the osseointegration of titanium implants. First, a series of yttrium-doped titanium surfaces were fabricated via microarc oxidation (MAO) by incorporating yttrium acetate into the electrolyte, and then the surface characteristics of different substrates were evaluated. Subsequently, the cellular behaviors of different coatings were assessed, and the osteointegration effects were examined using a rat model. Finally, high-throughput sequencing was employed to elucidate the underlying mechanisms of the yttrium-doped MAO coatings. As the results indicated, the proportion of yttrium in the coatings increased as the concentration of yttrium acetate improved. Surface characterization revealed that the yttrium-doped MAO coatings exhibited a homogeneous porous morphology, with comparable roughness and wettability to those of the undoped MAO coating, while the morphology became inconsistent when the yttrium acetate concentration reached 30 mM. The

Indexed as

Bone Morphogenetic ProteinsCoated Materials, BiocompatibleOsseointegrationSmad ProteinsTitaniumYttriumAnimalsCell AdhesionCell ProliferationMaleOsteogenesisOxidation-ReductionProstheses and ImplantsRatsRats, Sprague-DawleySignal TransductionBone Morphogenetic ProteinsCoated Materials, BiocompatibleSmad ProteinsTitaniumYttriumBMP/Smad pathwaymicroarc oxidationosteointegrationtitanium implantyttrium

Identifiers

PMID39945293
PMCPMC11897939

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.