Evidence map›Paper›PMID 39945250›Full record

ArticleCurrent HIV research2025

Latent Tuberculosis Screening and Active Tuberculosis Disease Development in People Living with HIV: A Multicenter Retrospective Cohort Study in Turkiye.

Ferit Kuscu, Figen Yildirim, Damla Erturk, Mehmet Cabalak, Suheyla Komur, Ayse Seza Inal, Behice Kurtaran, Yesim Tasova, Aslihan Candevir

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Current HIV research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ferit KuscuDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Cukurova University, Adana, Turkiye.
Figen YildirimDepartment of Infectious Diseases and Clinical Microbiology, Antalya Life Hospital, Antalya, Turkiye.
Damla ErturkDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Cukurova University, Adana, Turkiye.
Mehmet CabalakDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkiye.
Suheyla KomurDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Cukurova University, Adana, Turkiye.
Ayse Seza InalDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Cukurova University, Adana, Turkiye.
Behice KurtaranDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Cukurova University, Adana, Turkiye.
Yesim TasovaDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Cukurova University, Adana, Turkiye.
Aslihan CandevirDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Cukurova University, Adana, Turkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAbout 10% of individuals with latent tuberculosis infection (LTBI) develop tuberculosis (TB) disease during their lifetime. People living with HIV (PLWH) have a significantly higher risk of developing tuberculosis disease from latent tuberculosis infection (LTBI) compared to those without HIV. Many HIV treatment guidelines recommend screening and treating for LTBI.

objectiveThis study aimed to investigate the LTBI screening frequency of PLWH and the rates of tuberculosis disease development during their follow-up.

methodsA total of 483 PLWH were admitted to 3 research hospitals between January 2005 and April 2020. Patients who were 18 years and older, who did not have active TB disease, and who were followed up regularly were included in the study. Demographic characteristics and laboratory results of the patients, and tuberculin skin test (TST) and/or interferon gamma releasing assay (IGRA) results were recorded. Whether TB developed during the follow-up of the patients or not was recorded.

resultsA total of 482 PLWH were enrolled in the study, and 429 (89%) of them were male. The mean age of the patients was 37±13 years. The patients were followed for an average of 27.5 months (2-180 months). The mean CD4 count was 381±246/mm3 at the time of diagnosis. A total of 331 patients (68.7%) were screened for latent infection, and 62 (18.7%) of them were diagnosed with LTBI. During the follow-up of the patients, TB disease did not develop in anyone who was not screened for LTBI, while TB disease developed in 4 people who were screened. The mean age of PLWH who developed tuberculosis disease was 54±10 years, while those who did not develop it was 37±13 years, and the difference was statistically significant (p=0.009).

conclusionScreening for LTBI in PLWH and treating it when positive are recommended in the EACS guidelines. However, some local HIV guidelines recommend latent TB treatment according to ethnicity, CD4 count, and antiretroviral therapy use. Although the mean follow-up period was short, it was found that there was no difference in the development of TB disease in LTBIpositive and negative individuals in our study. For countries that are not on the list of high-burden countries for TB, it may be an option to give latent TB treatment only to selected patients who have lower CD4 counts.

Indexed as

HIV InfectionsLatent TuberculosisMass ScreeningTuberculosisAdultFemaleHumansInterferon-gamma Release TestsMaleMiddle AgedRetrospective StudiesTuberculin TestTurkeyYoung AdultAIDSHIVinterferon gamma releasing assayLatent tuberculosistuberculin skin testtuberculous screening.

Identifiers

PMID39945250

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.