Evidence map›Paper›PMID 39945132›Full record

ArticleAnnals of geriatric medicine and research2025

Angiotensin-Converting Enzyme Inhibitors versus Angiotensin Receptor Blockers in Older Patients with acute Myocardial Infarction after a Successful Stent Implantation.

Geum Ko, Jae-Geun Lee, Ki Yung Boo, Joon-Hyouk Choi, Song-Yi Kim, Seung-Jae Joo, Jin-Yong Hwang, Seung-Ho Hur, Seok Kyu Oh, Myung Ho Jeong

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of geriatric medicine and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Geum KoDepartment of Internal Medicine, Jeju National University Hospital, Jeju, Korea.
Jae-Geun LeeDepartment of Internal Medicine, Jeju National University Hospital, Jeju, Korea.
Ki Yung BooDepartment of Internal Medicine, Jeju National University Hospital, Jeju, Korea.
Joon-Hyouk ChoiDepartment of Internal Medicine, Jeju National University Hospital, Jeju, Korea.
Song-Yi KimDepartment of Internal Medicine, Jeju National University Hospital, Jeju, Korea.
Seung-Jae JooDepartment of Internal Medicine, Jeju National University Hospital, Jeju, Korea.
Jin-Yong HwangDepartment of Internal Medicine, Gyeongsang National University Hospital, Gyeonsang National University College of Medicine, Jinju, Korea.
Seung-Ho HurDepartment of Cardiovascular Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.
Seok Kyu OhDivision of Cardiology, Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea.
Myung Ho JeongDepartment Cardiovascular Center, Gwangju Veterans Hospital, Gwangju, Korea.

Funding

Korea Centers for Disease Control and Prevention 2016-ER6304-02
6 · The paper itself

Abstract

backgroundThis study aimed to evaluate the long-term clinical outcomes of patients with acute myocardial infarction (AMI) who underwent successful stent implantation and were subsequently treated with angiotensin-converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB).

methodsAmong 13,104 patients enrolled in the Korean AMI registry, 2,763 older patients aged 70 years or older, who were prescribed either ACEI or ARB at discharge, were included in this study. Propensity score matching (PSM) was performed to adjust for baseline confounders. The primary outcome was a composite of cardiac death and recurrent myocardial infarction (MI) at the 3-year follow-up.

resultsIn PSM cohort, use of ACEI at discharge was associated with a significantly lower incidence of primary outcome (hazard ratio, 1.60; 95% confidence interval, 1.20-2.14; p=0.001) compared to those of ARB at discharge. Additionally, incidences of cardiac death, recurrent MI and all-cause death were lower in use of ACEI at discharge than in those of ARB. However, there were no statistically significant differences between the two groups in hospitalization for heart failure, any revascularization, stent thrombosis, or stroke.

conclusionThe findings of this study suggest that ACEI use at discharge, compared with ARB use, was associated with lower incidences of cardiac death, and recurrent MI in older patients with AMI after successful stent implantation.

Indexed as

Angiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsMyocardial InfarctionStentsAgedAged, 80 and overFemaleHumansMalePropensity ScoreRecurrenceRegistriesRepublic of KoreaTreatment OutcomeAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsAngiotensin-converting enzyme inhibitorsMyocardial infarctionPropensity score

Identifiers

PMID39945132
PMCPMC12214979

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