Trial reportAnnals of geriatric medicine and research2025
Phase Angle following Intradialytic Neuromuscular Electrical Stimulation and Oral Protein Supplementation in Patients undergoing Chronic Hemodialysis.
Trial report in Annals of geriatric medicine and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Diagnostic performance of ultrasonographic medial gastrocnemius muscle thickness for sarcopenia in patients on maintenance hemodialysis.Frontiers in medicine · 2026Article
- Optimizing hemodialysis management using bioelectrical impedance analysis: emphasizing the significance of the phase angle.Renal failure · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSarcopenia is a prevalent condition in patients undergoing chronic hemodialysis. Therefore, a convenient and reliable method of monitoring muscle health is required. This study identified the utility of the phase angle (PhA) to estimate muscle health, and evaluated its changes following intradialytic neuromuscular electrical stimulation (NMES) and oral nutritional supplement interventions in patients undergoing chronic hemodialysis.
methodsThis post-hoc analysis was conducted using data obtained from a 12-week multicenter randomized trial that examined the effects of NMES and protein supplementation. The participants were divided into four groups according to intradialytic NMES and protein supplementation. The PhA, muscle mass, muscle strength, and physical performance were measured every 4 weeks.
resultsOverall, 59 participants completed the study. PhA values were linearly associated with muscle mass and muscle strength. Additionally, high PhA levels indicated fast gait speed and shortened timed up-and-go test (TUG) results. We further evaluated the association between the PhA slope and muscle health-related parameters. In participants with the PhA slope <0° over 12 weeks, TUG results worsened over time, relative to those with a slope ≥0° over 12 weeks, independent of age, sex, diabetes, and body mass index. NMES did not improve the PhA values over time; however, protein supplementation tended to increase the PhA values.
conclusionPhA is a reliable marker for estimating and monitoring muscle health in patients undergoing chronic hemodialysis, and a strong association exists between PhA and TUG results.
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