Evidence map›Paper›PMID 39945066›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2025

Restoring Vascular Smooth Muscle Cell Mitochondrial Function Attenuates Abdominal Aortic Aneurysm in Mice.

Yaozhong Liu, Minzhi Yu, Huilun Wang, Kristen Hong Dorsey, Yalun Cheng, Ying Zhao, Yonghong Luo, Guizhen Zhao, Yang Zhao, Haocheng Lu and 10 more

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Article in Arteriosclerosis, thrombosis, and vascular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. The role of neutrophils in the pathogenesis of abdominal aortic aneurysms.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  8. Article
  9. Article
  10. Aging-AssociatedJournal of the American Heart Association · 2026
    Article
  11. Emerging Mechanisms of Abdominal Aortic Aneurysm.Current atherosclerosis reports · 2026
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yaozhong Liu *Department of Internal Medicine, Frankel Cardiovascular Center (Y. Liu, H.W., Y.C., Ying Zhao, Y. Luo, G.Z., Yang Zhao, Y.D., W.M., H. Liu, X.W., Z.W., J.Z., L.C., Y.E.C., Y.G.), University of Michigan Medical Center, Ann Arbor.
Minzhi Yu *Department of Pharmacology, University of Michigan, Ann Arbor (M.Y., K.H.D., A.S.).ORCID 0000-0002-3141-7285
Huilun WangDepartment of Internal Medicine, Frankel Cardiovascular Center (Y. Liu, H.W., Y.C., Ying Zhao, Y. Luo, G.Z., Yang Zhao, Y.D., W.M., H. Liu, X.W., Z.W., J.Z., L.C., Y.E.C., Y.G.), University of Michigan Medical Center, Ann Arbor.
Kristen Hong DorseyDepartment of Pharmacology, University of Michigan, Ann Arbor (M.Y., K.H.D., A.S.).ORCID 0000-0003-2742-4658
Yalun ChengDepartment of Internal Medicine, Frankel Cardiovascular Center (Y. Liu, H.W., Y.C., Ying Zhao, Y. Luo, G.Z., Yang Zhao, Y.D., W.M., H. Liu, X.W., Z.W., J.Z., L.C., Y.E.C., Y.G.), University of Michigan Medical Center, Ann Arbor.
Ying ZhaoDepartment of Internal Medicine, Frankel Cardiovascular Center (Y. Liu, H.W., Y.C., Ying Zhao, Y. Luo, G.Z., Yang Zhao, Y.D., W.M., H. Liu, X.W., Z.W., J.Z., L.C., Y.E.C., Y.G.), University of Michigan Medical Center, Ann Arbor.
Yonghong LuoDepartment of Internal Medicine, Frankel Cardiovascular Center (Y. Liu, H.W., Y.C., Ying Zhao, Y. Luo, G.Z., Yang Zhao, Y.D., W.M., H. Liu, X.W., Z.W., J.Z., L.C., Y.E.C., Y.G.), University of Michigan Medical Center, Ann Arbor.
Guizhen ZhaoDepartment of Internal Medicine, Frankel Cardiovascular Center (Y. Liu, H.W., Y.C., Ying Zhao, Y. Luo, G.Z., Yang Zhao, Y.D., W.M., H. Liu, X.W., Z.W., J.Z., L.C., Y.E.C., Y.G.), University of Michigan Medical Center, Ann Arbor.ORCID 0000-0002-2648-8986
Yang ZhaoDepartment of Internal Medicine, Frankel Cardiovascular Center (Y. Liu, H.W., Y.C., Ying Zhao, Y. Luo, G.Z., Yang Zhao, Y.D., W.M., H. Liu, X.W., Z.W., J.Z., L.C., Y.E.C., Y.G.), University of Michigan Medical Center, Ann Arbor.ORCID 0000-0002-1428-5145
Haocheng LuDepartment of Pharmacology, Southern University of Science and Technology, Guangdong, China (H. Lu).ORCID 0000-0002-5740-8010
Yongjie DengDepartment of Internal Medicine, Frankel Cardiovascular Center (Y. Liu, H.W., Y.C., Ying Zhao, Y. Luo, G.Z., Yang Zhao, Y.D., W.M., H. Liu, X.W., Z.W., J.Z., L.C., Y.E.C., Y.G.), University of Michigan Medical Center, Ann Arbor.
Wenjuan MuDepartment of Internal Medicine, Frankel Cardiovascular Center (Y. Liu, H.W., Y.C., Ying Zhao, Y. Luo, G.Z., Yang Zhao, Y.D., W.M., H. Liu, X.W., Z.W., J.Z., L.C., Y.E.C., Y.G.), University of Michigan Medical Center, Ann Arbor.
Hongyu LiuDepartment of Internal Medicine, Frankel Cardiovascular Center (Y. Liu, H.W., Y.C., Ying Zhao, Y. Luo, G.Z., Yang Zhao, Y.D., W.M., H. Liu, X.W., Z.W., J.Z., L.C., Y.E.C., Y.G.), University of Michigan Medical Center, Ann Arbor.
Xiaokang WuDepartment of Internal Medicine, Frankel Cardiovascular Center (Y. Liu, H.W., Y.C., Ying Zhao, Y. Luo, G.Z., Yang Zhao, Y.D., W.M., H. Liu, X.W., Z.W., J.Z., L.C., Y.E.C., Y.G.), University of Michigan Medical Center, Ann Arbor.ORCID 0000-0003-1020-6232
Zhenguo WangDepartment of Internal Medicine, Frankel Cardiovascular Center (Y. Liu, H.W., Y.C., Ying Zhao, Y. Luo, G.Z., Yang Zhao, Y.D., W.M., H. Liu, X.W., Z.W., J.Z., L.C., Y.E.C., Y.G.), University of Michigan Medical Center, Ann Arbor.
Jifeng ZhangDepartment of Internal Medicine, Frankel Cardiovascular Center (Y. Liu, H.W., Y.C., Ying Zhao, Y. Luo, G.Z., Yang Zhao, Y.D., W.M., H. Liu, X.W., Z.W., J.Z., L.C., Y.E.C., Y.G.), University of Michigan Medical Center, Ann Arbor.ORCID 0000-0001-5161-4705
Lin ChangDepartment of Internal Medicine, Frankel Cardiovascular Center (Y. Liu, H.W., Y.C., Ying Zhao, Y. Luo, G.Z., Yang Zhao, Y.D., W.M., H. Liu, X.W., Z.W., J.Z., L.C., Y.E.C., Y.G.), University of Michigan Medical Center, Ann Arbor.
Y Eugene ChenDepartment of Internal Medicine, Frankel Cardiovascular Center (Y. Liu, H.W., Y.C., Ying Zhao, Y. Luo, G.Z., Yang Zhao, Y.D., W.M., H. Liu, X.W., Z.W., J.Z., L.C., Y.E.C., Y.G.), University of Michigan Medical Center, Ann Arbor.ORCID 0000-0003-2357-7825
Anna SchwendmanDepartment of Pharmacology, University of Michigan, Ann Arbor (M.Y., K.H.D., A.S.).ORCID 0000-0002-8023-8080
Yanhong GuoDepartment of Internal Medicine, Frankel Cardiovascular Center (Y. Liu, H.W., Y.C., Ying Zhao, Y. Luo, G.Z., Yang Zhao, Y.D., W.M., H. Liu, X.W., Z.W., J.Z., L.C., Y.E.C., Y.G.), University of Michigan Medical Center, Ann Arbor.ORCID 0000-0002-3334-9159

Funding

KLF14 and Cardiovascular DiseaseR01HL134569 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, YUQING EUGENE · 2017 to 2024
$5.3M
Development of phospholipid-based nanotherapeutics for treating abdominal aortic aneurysmR01HL165688 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Yanhong Guo, Anna Schwendeman · 2023 to 2026
$3.1M
Vascular smooth muscle cell ferroptosis and abdominal aortic aneurysmR01HL166203 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Yanhong Guo · 2023 to 2026
$2.7M
BAF60c and abdominal aortic aneurysmR01HL153710 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZHANG, JIFENG · 2021 to 2025
$2.7M
Smooth muscle cell PRDM16 and aortic aneurysmR01HL151524 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHANG, LIN · 2021 to 2024
$2.7M
Browning of perivascular adipose tissue protects against thoracic aortic aneurysmR01HL159871 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, YUQING EUGENE · 2022 to 2025
$2.3M
Metaboloepigenetics and AtherosclerosisR01HL172832 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Guizhen Zhao · 2024 to 2026
$1.8M
NHLBI NIH HHS R01 HL134569NHLBI NIH HHS R01 HL151524NHLBI NIH HHS R01 HL153710NHLBI NIH HHS R01 HL159871NHLBI NIH HHS R01 HL165688NHLBI NIH HHS R01 HL166203NHLBI NIH HHS R01 HL172832
6 · The paper itself

Abstract

backgroundAbdominal aortic aneurysm (AAA) is a complex vascular pathology without pharmaceutical interventions. This study aimed to evaluate whether restoring vascular smooth muscle cell (VSMC) mitochondrial function could prevent AAA development.

methodsAng II (angiotensin II)-induced AAA was established in

resultsVSMC mitochondrial damage intensified gradually during AAA development, which was confirmed in distinct AAA animal models and human tissues. sHDL accumulated in the aneurysmatic lesions and restored mitochondrial DNA levels and the expression of genes related to oxidative phosphorylation following Ang II infusion. In mouse primary VSMCs, sHDL maintained mitochondrial homeostasis by suppressing the upregulation of DRP1 (dynamin-related protein 1), a protein involved in mitochondrial fission, reducing the generation of reactive oxygen species, preventing the loss of mitochondrial membrane potential, and preserving mitochondrial respiratory capacity. Administration of sHDL decreased Ang II-induced AAA incidence (control versus treatment, 76% versus 40%;

conclusionsVSMC mitochondrial damage is a pivotal factor in the development of AAA. The utilization of sHDL nanoparticles represents a promising novel therapeutic approach for AAA, aimed at restoring VSMC mitochondrial function.

Indexed as

Aorta, AbdominalAortic Aneurysm, AbdominalMitochondriaMitochondria, MuscleMuscle, Smooth, VascularMyocytes, Smooth MuscleAngiotensin IIAnimalsCells, CulturedDisease Models, AnimalDNA, MitochondrialDynaminsHumansMaleMembrane Potential, MitochondrialMiceAngiotensin IIDNA, MitochondrialDnm1l protein, mouseDynaminsReactive Oxygen SpeciesReceptors, LDLaneurysmaortic aneurysm, abdominallipoproteins, HDLmitochondrial diseasestranscriptome

Identifiers

PMID39945066
PMCPMC12038981

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.