ReviewJournal of orthopaedic translation2025
Gradient scaffolds in bone-soft tissue interface engineering: Structural characteristics, fabrication techniques, and emerging trends.
Review in Journal of orthopaedic translation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling.FEBS open bio · 2026Review
- The Role of SERPINE1 in Coordinating Osteogenesis and Angiogenesis of hDPSCs for Bone Regeneration.International endodontic journal · 2026Article
- Engineering a biomimetic multiphasic suture anchor system for enhanced rotator cuff enthesis regeneration.Science advances · 2026Article
- Programmable continuous gradient bioprinting for engineering spatially heterogeneous microenvironments.Materials today. Bio · 2026Article
- Investigation into the Impact of Hollow Cylinder Inner Diameter on the Mechanical Properties of Biomimetic Voronoi Scaffolds.Journal of functional biomaterials · 2026Article
- Mechanical and biological properties of trabecula and strut scaffolds in bone defect reconstruction.BMC biotechnology · 2026Article
- Design and Fabrication of Biomimetic Gradient Bone Tissue Engineering Scaffolds: Evolution from Single-Gradient to Multi-Gradient.Gels (Basel, Switzerland) · 2026Review
- Shaping the mechanical properties of a gelatin hydrogel interface via amination.Journal of the mechanical behavior of biomedical materials · 2026Article
- Biomimetic Scaffolds and Extracellular Matrix-Based Strategies for Myofiber Regeneration in Volumetric Muscle Loss.Drug design, development and therapy · 2026Review
- Biomaterial strategies for precision regeneration of the tooth extraction socket: integrating site phenotype, pathological microenvironment, and healing sequence.Frontiers in bioengineering and biotechnology · 2026Review
- Advances in Functional Scaffolds for Bone and Joint Surgery.Journal of functional biomaterials · 2025Article
- Mimicking Design Scaffolds Based on Nonwoven Biological Materials of Silk Cocoon for Soft Tissue Engineering at the Bone Interfacial Area: Structure, Morphology, and Performance Evaluation Based on In Vitro Testing, and Identification of Applied Biomaterials.ACS applied bio materials · 2025Article
- Modeling and Experimental Validation of Gradient Cell Density in PMMA Microcellular Foaming Induced by One-Sided Heating.Polymers · 2025Article
- Recent advances in gradient biomimetic scaffolds for tendon-bone interface regeneration.Frontiers in bioengineering and biotechnology · 2025Review
- Bridging basic science and clinical practice in orthopaedic translational research.Journal of orthopaedic translation · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone and soft tissues are connected by a complex interface that is crucial for the smooth transfer of mechanical stress. Effective repair of this interface requires bio-scaffolds specifically designed to support the regeneration of diverse cell types and signalling molecules. With advances in micro- and nanotechnologies, gradient biomaterial scaffolds have demonstrated significant potential in interface tissue regeneration. This paper reviews the structure of the bone-soft tissue interface, the various gradient scaffold types, and construction methods. It also discusses the recent developments and future directions in interface tissue engineering, emphasizing the potential of gradient scaffolds to restore the natural structure and function of bone-soft tissue interfaces. Overall, this paper provides valuable insights into the application of gradient scaffolds for bone-soft tissue interface engineering, offering inspiration for biomimetic approaches to soft-hard interface repair in future medical engineering. The Translational Potential of this Article: First, the emphasis on gradient scaffolds could significantly impact clinical practices related to bone-soft tissue integration, ultimately improving patient outcomes and quality of life. Second, it also aligns with the growing trend of biomimetic approaches in medical engineering, potentially inspiring new innovations in bone-soft tissue repair strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.