RevieweGastroenterology2024
Spleen stiffness measurement as a non-invasive assessment in patients with portal hypertension.
Review in eGastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The use of spleen biomechanics in forensic pathology.International journal of legal medicine · 2026Article
- Development of a noninvasive ultrasound-based model for predicting high-risk esophageal varices in hepatitis-related cirrhosis.Ultrasonography (Seoul, Korea) · 2026Article
- An Explainable AI Framework for Continuous Monitoring, Risk Stratification, and Clinical Decision Support in Primary Biliary Cholangitis: Protocol for a Multiphase Development and Validation Study.JMIR research protocols · 2026Article
- Predicting post-hepatectomy liver failure after hemi-hepatectomy using a combined model based on age, ALBI score, and the future liver remnant-to-spleen volume ratio.Updates in surgery · 2026Article
- Splenic shear wave elastography beyond portal hypertension: a narrative review of non-portal applications.Journal of ultrasonography · 2026Review
- Innovations in liver disease assessment: clinical insights from spleen stiffness measurement in chronic liver diseases.Journal of translational medicine · 2026Review
- Dual cut-offs and beyond: Expanding the role of transient elastography in primary biliary cholangitis.World journal of gastroenterology · 2026Article
- Predicting Clinically Significant Portal Hypertension in MASLD Using Routine Ultrasound and Clinical Data: A Retrospective Cohort Study.BioMed research international · 2026Article
- Advances in endoscopic ultrasound-guided shear wave elastography: A comprehensive review of its clinical applications.World journal of gastroenterology · 2025Review
- The pathophysiological role of portal hypertension in metabolic dysfunction-associated steatotic liver disease.Hepatology communications · 2025Review
- Liver fibrosis with persistently normal alanine transaminase levels exhibits a distinct treatment response in MASLD.BMJ open gastroenterology · 2025Article
- Role of Spleen Stiffness Measurements with 2D Shear-Wave Elastography for Esophageal Varices in Patients with Compensated Advanced Chronic Liver Disease.Diagnostics (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For patients with advanced chronic liver disease who are in a compensated state, the development of portal hypertension (PHT) can lead to a heightened risk of hepatic decompensation and mortality. This underscores the importance of timely and appropriate treatment to manage the condition and prevent further complications. The current gold standard procedure for determining PHT is the hepatic venous pressure gradient, but its invasiveness limits its usage in clinical practice and larger trials of novel agents. The current clinical demand for accurate, validated and non-invasive methods to assess the severity of PHT remains unmet. One potential non-invasive option is tissue elastography, which examines the elastic behaviour of tissue after a force has been applied. This method involves quantifying alterations in the biomechanical properties of the liver or spleen in patients with cirrhosis. Available methods are various, including transient elastography, shear wave elastography, acoustic radiation force impulse and magnetic resonance elastography. Importantly, the measurement of spleen stiffness appears to outperform liver stiffness as a direct and dynamic indicator of portal pressure, offering the potential to monitor PHT and evaluate improvements in PHT as a marker for clinical outcomes.
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