Evidence map›Paper›PMID 39944704›Full record

ReviewFrontiers in immunology2025

Sinonasal small-cell carcinoma combined concurrently with small-cell lung carcinoma: case report and literature review.

Rencui Quan, Ling Han, Shihai Wu, Xianming Li

Abstract readCase ReportsReview
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rencui Quan *Jinan University, Guangzhou, China.
Ling Han *Department of ENT, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.
Shihai WuDepartment of Radiation Oncology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.
Xianming LiDepartment of Radiation Oncology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sinonasal small-cell neuroendocrine carcinoma (SCNEC) is an uncommon malignant epithelial neuroendocrine tumor in the sinonasal cavity that often presents in isolation and rarely occurs in synchronous fashion with small-cell lung carcinoma (SCLC). Here, we present a case of a 65-year-old man diagnosed with SCNEC concurrently combined with SCLC. He received first-line platinum-doublet chemotherapy combined with durvalumab, followed by radiotherapy to thoracic as well as head and neck regions. The follow-up computed tomography and magnetic resonance imaging showed a complete response according to Response Evaluation Criteria in Solid Tumors criteria until 9 June 2024. This case highlights the need for accurate diagnostic characterization of primary lesions and the need to formalize treatment paradigms using chemotherapy, radiation therapy, immunotherapy with immune checkpoint inhibitors, and targeted prophylactic cranial irradiation.

Indexed as

Carcinoma, NeuroendocrineCarcinoma, Small CellLung NeoplasmsNeoplasms, Multiple PrimaryParanasal Sinus NeoplasmsSmall Cell Lung CarcinomaAgedAntineoplastic Combined Chemotherapy ProtocolsHumansMaleimmune checkpoint inhibitorsmaintenance treatmentPD-L1sinonasal small cell neuroendocrine carcinomasmall cell lung carcinoma (SCLC)

Identifiers

PMID39944704
PMCPMC11814467

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.