Evidence map›Paper›PMID 39944646›Full record

ReviewFrontiers in microbiology2025

Response of alcohol fermentation strains, mixed fermentation and extremozymes interactions on wine flavor.

Ling-Zhi Zhao, Jing Chen, Xiang-Ying Wei, Bo Lin, Feng-Jin Zheng, Krishan K Verma, Gan-Lin Chen

Abstract readReview
In one paragraph

Review in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Multi-omics insights into co-fermentation byFrontiers in nutrition · 2026
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ling-Zhi Zhao *College of Light Industry and Food Engineering, Guangxi University, Nanning, China.
Jing Chen *Guangxi Subtropical Crops Research Institute, Guangxi Academy of Agricultural Sciences, Nanning, China.
Xiang-Ying WeiGuangxi Subtropical Crops Research Institute, Guangxi Academy of Agricultural Sciences, Nanning, China.
Bo LinInstitute of Agro-Products Processing Science and Technology, Guangxi Academy of Agricultural Sciences, Nanning, China.
Feng-Jin ZhengInstitute of Agro-Products Processing Science and Technology, Guangxi Academy of Agricultural Sciences, Nanning, China.
Krishan K VermaSugarcane Research Institute, Guangxi Academy of Agricultural Sciences, Nanning, China.
Gan-Lin Chen *Guangxi Subtropical Crops Research Institute, Guangxi Academy of Agricultural Sciences, Nanning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Winemaking, one of the ancient technologies, is simply the process of converting sugar into alcohol through a complex biochemical reaction. The process of winemaking involves a complex of enological technique that faces a host of challenges in a winery including, inconsistent quality due to chemical and microbiological instability, limited sensory flavor profiles, and concerns met with changing micro-environmental conditions. Fermentation is a metabolic process where the chemical composition of an organic substrate is fragmented via the cellular enzymes under anaerobic conditions. Mixed fermentation, which involves using multiple strains, can enhance the aroma of fermented food, overcome the limitations of single strain fermentation, and improve flavor and quality of food. Mixed fermentation has important applications for agro-food industries, healthcare products and medical sciences. The modern mixed fermentation process showed the enhancement of wine aroma, flavor and taste, reducing volatile acidity and upregulating the phenylethyl acetate concentration through synergistic effect of multiple microorganisms. Key microorganisms in alcohol fermentation, such as yeast, lactic acid and acetic acid bacteria, interact with each other during alcohol fermentation process affects the quality and flavor of the wine. Extremophilic microorganisms have established different molecular strategies to survive amidst the adverse conditions. Biocatalysts isolated by these organisms are termed extremozymes and possess extraordinary properties of salt allowance, thermostability, and cold adaptability. However, the physicochemical and sensory properties of alcohol are important to the quality of end-use products. Therefore, when optimizing fermentation conditions, selecting a right combination of microorganisms is the key to derive better physicochemical and sensory properties. However, the use of mixed fermentation and extremozymes can provide significant insight and potential remedial solutions to overcome these technical problems and shape the final product in more desirable and sustainable ways, challenging the current shortcomings to deliver a more resilient end-products with consistent, flavorful, and a number of what may be considered remedial techniques can be employed to produce an acceptable product to consumers.

Indexed as

alcohol fermentationbacteriaextremophilessingle and mixed strain fermentationstrain improvementwine flavor

Identifiers

PMID39944646
PMCPMC11813877

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.