ArticleFrontiers in public health2024
Association between fluoride exposure and the risk of serum CK and CK-MB elevation in adults: a cross-sectional study in China.
Article in Frontiers in public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study aimed to investigate the relationship between urinary fluoride concentration and myocardial disease. Methods: This is a cross-sectional study that was conducted in three villages in Wenshui County, Shanxi Province. A total of 737 villagers were included in this analysis. Urinary fluoride was detected using a fluoride-ion selective electrode. Myocardial enzymes were detected using an automatic biochemical analyzer. Myocardial ischemia and arrhythmia were diagnosed using 12-lead electrocardiogram. Results: The median level of urinary fluoride concentration was 1.32 mg/L. Urinary fluoride was associated with serum creatine kinase (CK) elevation (odds ratio [OR] = 1.39 [95% confidence interval (CI)]: 1.09-1.78) and CK isoenzyme (CK-MB) elevation (OR = 1.49 [95% CI: 1.12-1.97]). Stratified analysis revealed that urinary fluoride concentration was associated with CK elevation in villagers under the age of 60 years (OR = 1.80 [95% CI: 1.26-2.59]). This study found that there was a positive association between urinary fluoride concentration and the risk of CK-MB elevation in participants under the age of 60 years(OR = 2.18 [95% CI: 1.39-3.42]), those who were of female gender (OR = 1.53 [95% CI: 1.07-2.19]), those who were overweight/obese (OR = 1.96 [95% CI: 1.28-2.99]), those who had central obesity (OR = 1.59 [95% CI: 1.12-2.25]), consumed alcohol (OR = 1.49 [95% CI: 1.09-2.05]), and smoked (OR = 1.50 [95% CI: 1.10-2.04]). Conclusion: Our study suggests that fluoride exposure is associated with the risk of serum CK and CK-MB elevation; however, it is not associated with myocardial ischemia, arrhythmia, serum lactate dehydrogenase (LDH), serum alpha-hydroxybutyrate dehydrogenase (
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