Evidence map›Paper›PMID 39944453›Full record

ReviewCureus2025

Platelet-Rich Plasma Effectiveness in Treating Androgenetic Alopecia: A Comprehensive Evaluation.

Rúben Lopes-Silva, Maria Santos, Maria Luísa Sequeira, Andreia Silva, Tatiana Antunes, Paulo Valejo-Coelho, Manuel Neiva-Sousa

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rúben Lopes-SilvaDepartment of Maxillofacial Surgery, Unidade Local de Saúde de São José, Lisbon, PRT.
Maria SantosDepartment of Maxillofacial Surgery, Unidade Local de Saúde de São José, Lisbon, PRT.
Maria Luísa SequeiraDepartment of Head and Neck Surgery, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, PRT.
Andreia SilvaDepartment of Maxillofacial Surgery, Unidade Local de Saúde de São José, Lisbon, PRT.
Tatiana AntunesDepartment of Maxillofacial Surgery, Unidade Local de Saúde de São José, Lisbon, PRT.
Paulo Valejo-CoelhoDepartment of Maxillofacial Surgery, Unidade Local de Saúde de São José, Lisbon, PRT.
Manuel Neiva-SousaFunctional Unit of Maxillofacial Surgery, Unidade Local de Saúde Alto Ave, Guimarães, PRT.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platelet-rich plasma (PRP) has gained recognition in regenerative medicine due to its concentration of growth factors that promote hair follicle activity, making it a potential treatment for androgenetic alopecia (AGA). However, variability in PRP preparation and application has led to inconsistent outcomes across studies. This review evaluates the overall effectiveness of PRP in treating AGA based on the latest available evidence. A systematic search was conducted in PubMed, identifying 156 articles related to PRP and AGA. After applying inclusion and exclusion criteria, 11 studies published between January 2020 and May 2024 were selected. The studies focused on the efficacy of PRP compared to placebo or other treatments and explored different PRP formulations and application methods. The majority of studies demonstrated that PRP is effective in increasing hair density and thickness in patients with AGA. There was a general consensus on the positive effects of PRP, although results varied due to differences in preparation protocols, platelet concentration, and delivery methods. Additionally, combining PRP with other treatments, such as microneedling or topical medications like minoxidil, showed enhanced efficacy in several studies. While some studies reported conflicting outcomes, the overall evidence supports PRP as a promising treatment for AGA. In conclusion, PRP is a viable therapeutic option for AGA, particularly for increasing hair density and thickness. However, the variability in treatment protocols highlights the need for standardized PRP preparation and application methods. Future research should focus on refining these protocols and exploring the potential of combination therapies to maximize treatment effectiveness and consistency.

Indexed as

agaandrogenetic alopeciahair follicleplatelet-rich plasmaprp

Identifiers

PMID39944453
PMCPMC11817460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.