ArticleCureus2025
Association of Hypocapnia With Febrile Seizures: A Cross-Sectional Observational Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
backgroundFebrile seizures are a benign condition with unexplained pathophysiology. Respiratory alkalosis due to increased temperature can cause cerebral alkalosis and seizures.
objectivesThe objective of this study is to assess the association of hypocapnia and respiratory alkalosis with the time of presentation after febrile seizures. STUDY
designThis is a cross-sectional observational study.
participantsA total of 51 children admitted to SRM Medical College Hospital over a period of one year (September 2020-September 2021) were included in the study.
interventionVenous blood gas was measured at admission. The presence of hypocapnia and respiratory alkalosis were analyzed along with the time of admission from the onset of seizures.
resultsWhen comparing temperature values with pH values as a linear regression, there was a positive correlation (r = 0.39, P = 0.005). Children who presented earlier were more likely to have respiratory alkalosis compared to those who presented late (P = 0.000).
conclusionsFebrile seizures could be associated with blood pH changes, making way for newer therapeutic approaches and the need for subsequent clinical trials.
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