ArticleCureus2025
Accidental Intrathecal Morphine Overdose During the Surgery: A Case Report and Literature Review.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Neuraxial anesthetic techniques have become part of the multimodal analgesia approach for gynecologic surgeries. Specifically, intrathecal morphine is one of the opioids most commonly used for prolonged pain management postoperatively. However, doses above a certain threshold pose a greater risk of adverse effects, especially respiratory complications. This case highlights the challenges faced during the management of an accidental administration of a tenfold dose of morphine in the subarachnoid space for a patient subjected to major gynecologic surgery. Surprisingly, yet to our advantage, the patient exhibited no evidence of the anticipated adverse effects and no further intervention was required. A key indicator that was crucial in identifying the mistake was a diminution in the minimal alveolar concentration (MAC) of the anesthetic agent used.
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