Evidence map›Paper›PMID 39944371›Full record

ArticleSovremennye tekhnologii v meditsine2023

Valve Formation during Colostomy by Means of Spherical Implants Based on Titanium Nickelide Both Wrapping and Non-Wrapping the Serous-Muscular Layer of the Intestine.

V I Korobeinikova, G Ts Dambaev, S G Anikeev, V N Khodorenko, O A Kaydash, M V Bukterov, A A Ufandeev, D V Vasilchenko, E A Avdoshina, M M Soloviev and 2 more

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Article in Sovremennye tekhnologii v meditsine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

V I KorobeinikovaPhD Student, Department of Hospital Surgery with a Course on Cardiovascular Surgery; Siberian State Medical University, 2 Moskovsky Trakt St., Tomsk, 634050, Russia.
G Ts DambaevMD, DSc, Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Hospital Surgery with a Course on Cardiovascular Surgery; Siberian State Medical University, 2 Moskovsky Trakt St., Tomsk, 634050, Russia.
S G AnikeevPhD, Head of the Laboratory of Medical Materials Science; National Research Tomsk State University, 50 Lenin Ave., Tomsk, 366340, Russia.
V N KhodorenkoPhD, Senior Researcher, Laboratory of Medical Materials and Shape Memory Implants, Siberian Institute of Physics and Technology named after Academician V.D. Kuznetsov; National Research Tomsk State University, 50 Lenin Ave., Tomsk, 366340, Russia.
O A KaydashPhD, Associate Professor, Department of Pharmacology; Siberian State Medical University, 2 Moskovsky Trakt St., Tomsk, 634050, Russia; Senior Researcher, Center for Preclinical Research at the Central Research Laboratory; Siberian State Medical University, 2 Moskovsky Trakt St., Tomsk, 634050, Russia.
M V BukterovSpecialist in Laboratory Animals, Vivarium of the Center for Preclinical Research at the Central Research Laboratory; Siberian State Medical University, 2 Moskovsky Trakt St., Tomsk, 634050, Russia.
A A UfandeevJunior Researcher, Center for Preclinical Research at the Central Research Laboratory; Siberian State Medical University, 2 Moskovsky Trakt St., Tomsk, 634050, Russia.
D V VasilchenkoMD, PhD, Associate Professor, Department of Pathological Anatomy; Siberian State Medical University, 2 Moskovsky Trakt St., Tomsk, 634050, Russia.
E A AvdoshinaMD, PhD, Associate Professor, Department of Hospital Surgery with a Course on Cardiovascular Surgery; Siberian State Medical University, 2 Moskovsky Trakt St., Tomsk, 634050, Russia.
M M SolovievMD, DSc, Professor, Department of Hospital Surgery with a Course on Cardiovascular Surgery; Siberian State Medical University, 2 Moskovsky Trakt St., Tomsk, 634050, Russia.
N E KurtseitovMD, DSc, Professor, Department of Hospital Surgery with a Course on Cardiovascular Surgery; Siberian State Medical University, 2 Moskovsky Trakt St., Tomsk, 634050, Russia.
V E GunterDSc, Professor, Department of Metal Physics; National Research Tomsk State University, 50 Lenin Ave., Tomsk, 366340, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Imposition of a classic colostomy does not allow to control the passage of intestinal discharge. This shortcoming provides rationale for development of new materials for implants, as well as new techniques for valve formation. Materials and Methods: Experiments were performed on 45 male Wistar rats with the average body weight of 587±10 g. Depending on the type of surgical intervention, all animals were divided into three groups. In the control group (n=15), a classic end colostomy was formed without spherical implants. In test group 1 (n=15), colostomy was formed using spherical implants made of titanium nickelide with wrapping the serous-muscular layer of the intestine; in test group 2 (n=15), the same procedure was performed without wrapping the serous-muscular layer. To assess the clinical condition of the animals, the authors monitored the body weight dynamics, food and water consumption, signs of discharge from the stoma, and recorded complications. The animals were euthanized on day 7, day 30, and day 60 of the experiment. During necropsy, the condition of the abdominal organs was assessed macroscopically with a special attention to the signs of adhesions. The severity of the inflammatory process in the area of surgical intervention was assessed histologically. Results: The survival rate in three groups was 100%. In the group with the formation of a colostomy non-wrapping the serous-muscular layer, a good effect of regeneration in the stoma area was shown, the connection of the skin flap and the intestinal wall was complete. Macroscopically, adhesions and inflammatory processes of the peritoneum in the control and two test groups were minimal. Conclusion: The present study shows the advantage of experimental modeling of colostomy using spherical titanium nickelide implants non-wrapping the serous-muscular layer of the colon compared to classical formation of colostomy. At that, wrapping the serous-muscular layer of the colon using spherical titanium nickelide implants is behind classical formation of a colostomy.

Indexed as

ColostomyNickelRats, WistarTitaniumAnimalsMaleProstheses and ImplantsRatsNickelTitaniumtitanium nickelidecolostomyneosphincterserous-muscular sphinctertitanium nickelide

Identifiers

PMID39944371
PMCPMC11811834

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