ReviewFrontiers in bioengineering and biotechnology2025
Application of biomaterials in mesenchymal stem cell based endometrial reconstruction: current status and challenges.
Review in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Stem cell therapy for intrauterine adhesions: a systematic review and meta-analysis of clinical outcomes.BMC pregnancy and childbirth · 2025Pooled it
- Effect of hUCMSC-seeded hydroxyapatite-chitosan scaffolds on immunomodulatory cytokine expression during alveolar socket healing: an in vivo study.Odontology · 2026Article
- Hydrogel-Based Systems in Intrauterine Adhesions: Bridging the Gap from Bench to Bedside.Advanced healthcare materials · 2026Review
- Alveolar socket preservation with human umbilical cord mesenchymal stem cell-seeded hydroxyapatite-chitosan scaffolds: An in vivo assessment of osteoprotegerin and receptor activator of nuclear factor-κB expression.Journal of molecular histology · 2026Article
- Mesenchymal stem cell-based therapeutic strategies for female infertility: current evidence and emerging targeting approaches.Biotechnology letters · 2026Review
- Comparative Analysis of Vehicles for the Regeneration of Mouse Endometrial Damage Model.Tissue engineering and regenerative medicine · 2026Article
- Hydrogel Microspheres for Biomedical Applications.Small science · 2026Review
- Molecular pathways and immune microenvironment regulation in stem cell therapy for thin endometrium: a comprehensive narrative review.Frontiers in immunology · 2026Review
- Biomaterials for fetal membrane repair in preterm premature rupture of membranes: advances in tissue engineering strategies.Journal of biological engineering · 2025Review
- Effects of miR-210-3p/SDF2 and miR-31-5p/FGF7 from hypoxic endometrial exosomes on UCB-MSC proliferation, migration, and differentiation.Stem cell research & therapy · 2025Article
- Chitosan-based Biomaterials in Regenerative Medicine: Optimizing Mesenchymal Stem Cell Viability and Function.Stem cell reviews and reports · 2025Review
- Immune-related gene signatures of thin endometrium: a transcriptomic and single-cell study.Frontiers in endocrinology · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe endometrial injuries may cause thin endometrium and intrauterine adhesion in women which can result in uterine factor infertility. Current treatments, including surgical separation of adhesions and hormonal regeneration of the endometrium, often fail to prevent re-adhesion and achieve satisfactory reproductive results. Recently, mesenchymal stem cells (MSCs) have become a promising new treatment for IUA. However, challenges such as cell survival and transplantation limit the effectiveness of MSC therapy. Researchers have explored various approaches to enhance the therapeutic efficiency of MSCs. Among these, biomaterials have been frequently employed due to their biocompatibility, degradability, and ability to provide a conducive environment for cell growth. This review discusses the use of various biomaterials in MSC-based therapies for endometrial reconstruction and summarizes evidence from preclinical and clinical studies, highlighting the efficacy and safety of these biomaterials. The review also addresses future directions in this field, such as advances in biomaterial engineering, new biomaterials currently under investigation, and personalized medicine approaches. This review emphasizes the significance of biomaterials in MSC-based therapy for endometrial reconstruction and provides practical guidance for developing new materials and treatment protocols for clinical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.