Evidence map›Paper›PMID 39944153›Full record

ArticleJCEM case reports2025

Rapidly Growing Thyroid Schwannoma: Diagnostic Challenges and Management Strategies.

Freddy J K Toloza, Armando Filie, Mark Raffeld, Electron Kebebew, Joanna Klubo-Gwiezdzinska, Sriram Gubbi

Abstract readCase Reports
In one paragraph

Article in JCEM case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Freddy J K TolozaMetabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0002-0123-5640
Armando FilieDepartment of Cytopathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Mark RaffeldDepartment of Molecular Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Electron KebebewDepartment of Surgery, Stanford Medical Center, Palo Alto, CA 94304, USA.
Joanna Klubo-GwiezdzinskaMetabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0001-8633-4420
Sriram GubbiMetabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0002-9263-1381

Funding

Studies of Thyroid Function in Health and DiseaseZIEDK075005 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KLUBO-GWIEZDZINSKA, JOANNA · 2013 to 2024
$2.3M
Intramural NIH HHS ZIE DK075005
6 · The paper itself

Abstract

Thyroid nodules are one of the most commonly encountered conditions in clinical endocrinology. Most thyroid nodules are of epithelial origin. However, primary thyroid mesenchymal tumors (TMTs), arising from the mesenchymal tissue, are being increasingly recognized. More than 20 different forms of benign and malignant TMTs have been described in the literature. Thyroid schwannoma is an extremely rare type of TMT, with only a few cases reported to date, accounting for less than 1% of all schwannomas. It primarily affects adults, with no significant sex predilection, and is often discovered incidentally during evaluation for thyroid nodules. Due to its rarity, the clinical presentation and natural history remain poorly understood, underscoring the importance of histopathological examination for accurate diagnosis and management. We describe a case of a patient with thyroid schwannoma who was diagnosed and managed at our center, contributing valuable insights to the limited body of knowledge on this rare entity. This is followed by a detailed description of the clinical features, diagnosis, and management of thyroid schwannomas.

Indexed as

mesenchymal tumorsschwannomaspindle cellsthyroid

Identifiers

PMID39944153
PMCPMC11815493

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.