Evidence map›Paper›PMID 39944095›Full record

ArticleJPGN reports2025

Drug-induced liver injury from Deferasirox in a pediatric patient with hereditary spherocytosis: A case report.

Siddhant Talwar, Blake Rosenthal, Madhav Vissa, Kayla Cort, Joshua Byers, Sabina Ali

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PubMed Full text at PMC Publisher
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Article in JPGN reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Siddhant TalwarDepartment of Pediatrics UCSF Benioff Children's Hospital-Oakland Oakland California USA.ORCID https://orcid.org/0009-0006-1391-4006
Blake RosenthalDivision of Pediatric Gastroenterology, Department of Pediatrics Children's Hospital Los Angeles Los Angeles California USA.
Madhav VissaDivision of Pediatric Hematology, Department of Pediatrics UCSF Benioff Children's Hospital-Oakland Oakland California USA.
Kayla CortDivision of Pediatric Radiology, Department of Pediatrics UCSF Benioff Children's Hospital-Oakland Oakland California USA.
Joshua ByersDepartments of Pathology and Laboratory Medicine UCSF San Fransisco California USA.
Sabina AliDivision of Pediatric Gastroenterology, Department of Pediatrics UCSF Benioff Children's Hospital-Oakland Oakland California USA.ORCID https://orcid.org/0000-0002-5887-5454

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with hereditary spherocytosis (HS) often require red blood cell transfusions for the treatment of hemolytic anemia. Iron overload is a known complication of frequent transfusions. Deferasirox, an oral iron chelator, can cause transient elevations in serum aminotransferase levels. There have been a few cases demonstrating Deferasirox-associated liver injury in patients with sickle cell anemia and thalassemia. In this case report, we present a 13-year-old male with transfusion-dependent HS treated with Deferasirox who presented with jaundice and was found to have evidence of acute hepatocellular injury.

Indexed as

anemiachelationhepatocellular injuryhyperbilirubinemia

Identifiers

PMID39944095
PMCPMC11810811

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.