ArticleFrontiers in psychology2025
Sleep as a mediator between chronic diseases and depression: a NHANES study (2005-2018).
Article in Frontiers in psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Quality of Life, Menopausal Symptoms, Insomnia and Depression in Peri- and Post-Menopausal Women: A Cross-Sectional Study.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Correlation analysis between sleep quality and depressive symptoms among rural elderly in China: An observational study.World journal of psychiatry · 2025Article
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5 authors.
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Abstract
Objective: This article investigates the relationship between common chronic diseases and depression among US adults and examines the mediating role of sleep in this relationship, using a cross-sectional study to offer recommendations for depression prevention. Methods: This study analyzed data from 10,710 participants collected from the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2018. Logistic regression, subgroup analysis, restricted cubic spline (RCS) analysis, and mediation analysis were employed to explore the relationship between common chronic diseases and depression, and the mediating role of sleep. Results: The adjusted model indicated that stroke (OR = 1.712, 95% CI: 1.399, 2.103), heart disease (OR = 1.419, 95% CI: 1.262, 1.598), diabetes (OR = 1.243, 95% CI: 1.116, 1.386), and hypertension (OR = 1.249, 95% CI: 1.160, 1.346) were associated with an increased probability of depression. Additionally, trouble sleeping (OR = 2.059, 95% CI: 1.790, 2.375) was associated with an increased probability of depression, while sleep hours (OR = 0.867, 95% CI: 0.846, 0.888) may decrease this probability. RCS analysis showed a non-linear relationship between sleep hours and the risk of depression. The final mediation analysis showed that trouble sleeping mediated 3.66% of the effect of stroke, 12.68% of heart disease, and 17.76% of diabetes on depression. Furthermore, trouble sleeping mediated 11.07% of the impact of hypertension on depression, while sleep hours mediated 5.36% of this impact. Conclusion: Chronic diseases and sleep problems may increase the likelihood of depression among U.S. adults, with sleep serving as a mediator between chronic diseases and depression.
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