Evidence map›Paper›PMID 39943889›Full record

ArticleActa ophthalmologica2025

Prototype master protocol for benchmarking of real-world follow-up data in glaucoma.

Pekko Hujanen, Anja Tuulonen, Sanna Leinonen, Kristian Vepsäläinen, Gauti Jóhannesson, Anu Vaajanen, Eemil Lehtonen, Hannele Uusitalo-Jarvinen

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta ophthalmologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pekko HujanenTays Eye Centre, Tampere University Hospital, Tampere, Finland.ORCID https://orcid.org/0000-0002-5932-1568
Anja TuulonenTays Eye Centre, Tampere University Hospital, Tampere, Finland.ORCID https://orcid.org/0000-0003-1077-3691
Sanna LeinonenTays Eye Centre, Tampere University Hospital, Tampere, Finland.ORCID https://orcid.org/0000-0002-6067-6972
Kristian VepsäläinenTays Eye Centre, Tampere University Hospital, Tampere, Finland.
Gauti JóhannessonDepartment of Clinical Sciences, Ophthalmology, Umeå University, Umeå, Sweden.ORCID https://orcid.org/0000-0003-0218-4563
Anu VaajanenEye and Vision Research SILK, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID https://orcid.org/0000-0001-9637-2156
Eemil LehtonenFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Hannele Uusitalo-JarvinenTays Eye Centre, Tampere University Hospital, Tampere, Finland.ORCID https://orcid.org/0000-0002-2030-295X

Funding

Eemil Aaltonen FoundationFinnish Ophthalmologist AssociationLUX-Foundation for Glaucoma ResearchSilmäsäätiöTampere University Hospital T63464Tampere University Hospital Support Foundation, Tampere University Hospital, Wellbeing services county of Pirkanmaa T64124The Competitive Research Funding of the Pirkanmaa Wellbeing Services County 9AA076The Competitive Research Funding of the Pirkanmaa Wellbeing Services County 9X060The Competitive Research Funding of the Pirkanmaa Wellbeing Services County MJ006HThe Competitive Research Funding of the Pirkanmaa Wellbeing Services County MK270The Competitive Research Funding of the Pirkanmaa Wellbeing Services County MK343The Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital 9AC095The Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital 9X081
6 · The paper itself

Abstract

purposeThe purpose of this study was to create a prototype master protocol for benchmarking glaucoma real-world data (RWD). Benchmarking is part of the digital innovation strategy of the Finnish aces-rwm ecosystem (automation of care and evaluation of the system with real-world monitoring).

methodsWe collected glaucoma RWD in 2012-17 at Tampere University Hospital (Tays) and compared them to six published RWD sets (one in Sweden and five in England). Visual field (VF) data at Tays were retrieved from the perimeter, and clinical RWD were collected manually. At baseline, VF data were available in 2511 of 4121 glaucoma patients (61%), of whom 1413 patients (56%) had 5 years of VF follow-up by 2017 (34% of all 4121 patients). Mean deviation (MD) data were analysed in multiple ways, considering also age and intraocular pressure (IOP).

resultsIn most data sets, higher age was related to faster progression. At Tays, the distributions of progression rates were similar in better and worse eyes. The proportions of eyes at Tays with the medium rate of MD progression (17% for 0.5-1.5 dB/year) and the fast rate (6% for >1.5 dB/year) were similar to the published RWD trial in England. The published datasets show significant variability in how their findings were reported.

conclusionsThis study represents a first step toward the development of a master protocol for real-world benchmarking of glaucoma care. Further refinement of the protocol will encourage and require national and international collaboration in order to produce comprehensive and comparable real-world EHR data sets.

Indexed as

BenchmarkingGlaucomaIntraocular PressureVisual FieldsAdultAgedAged, 80 and overDisease ProgressionFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesVisual Field Testsbenchmarkingglaucomamaster protocolprogressionreal‐world data

Identifiers

PMID39943889
PMCPMC12235677

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.