Evidence map›Paper›PMID 39943805›Full record

ArticleActa biochimica et biophysica Sinica2025

Ageing-associated gut dysbiosis deteriorates mouse cognition.

Huihui Ju, Yile Zhou, Wanting Wei, Yan Hu, Hongwei Fang, Zhouyi Chen, Xia Sun, Yi Shi, Hao Fang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huihui JuDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Yile ZhouDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Wanting WeiDepartment of Anesthesiology, Minhang Branch, Zhongshan Hospital, Fudan University, Shanghai 201199, China.
Yan HuDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Hongwei FangDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Zhouyi ChenDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Xia SunDepartment of Anesthesiology, Shanghai Geriatric Medical Center, Fudan University, Shanghai 200032, China.
Yi ShiShanghai Key Laboratory of Organ Transplantation, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Hao FangDepartment of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ageing is an independent factor for cognitive dysfunction. Ageing-associated alterations in the gut microbiota also affect cognition. The present study is designed to investigate changes in the gut microbiota and their participation in ageing-associated cognitive impairment. Both 10-week-old and 18-month-old mice are used. Mouse cognition is examined by novel object recognition and T-maze tests. Mouse feces are collected for sequencing and transplantation. Protein expression in the mouse intestine and hippocampus is studied using immunohistochemistry and immunofluorescence staining. Senescent neurons are induced by hydrogen peroxide

Indexed as

AgingCognitionCognitive DysfunctionDysbiosisGastrointestinal MicrobiomeAdenosine TriphosphateAnimalsFecal Microbiota TransplantationHippocampusMaleMiceMice, Inbred C57BLNeuronsSynaptophysinAdenosine TriphosphateSynaptophysinacetic acidageingcognition impairmentgut microbiota transplantation

Identifiers

PMID39943805
PMCPMC12368526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.