Evidence map›Paper›PMID 39943185›Full record

ReviewAnimals : an open access journal from MDPI2025

Trilostane: Beyond Cushing's Syndrome.

Ali R Olaimat, Parastoo Jafarzadehbalagafsheh, Mohammad Gol, Anna-Maria Costa, Giuseppe Biagini, Chiara Lucchi

Abstract readReview
In one paragraph

Review in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ali R OlaimatLaboratory of Experimental Epilepsy, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0009-0007-6079-6062
Parastoo JafarzadehbalagafshehLaboratory of Experimental Epilepsy, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0009-0001-6171-2197
Mohammad GolRadiology Department, South Tyneside and Sunderland NHS Foundation Trust, Sunderland SR4 7TP, UK.ORCID 0000-0001-5189-1008
Anna-Maria CostaLaboratory of Experimental Epilepsy, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Giuseppe BiaginiLaboratory of Experimental Epilepsy, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0002-7130-2511
Chiara LucchiLaboratory of Experimental Epilepsy, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.

Funding

European Union. Next Generation EU PRIN 2022Ministry of Health RF-2021- 12373036Ministry of University and Research 20228XNEC4
6 · The paper itself

Abstract

Trilostane is a drug able to block the synthesis of progesterone from pregnenolone, dependent on the enzyme 3β-hydroxysteroid dehydrogenase/Δ

Indexed as

allopregnanolonebrainCushing’s syndromeepilepsyneurosteroidstrilostane

Identifiers

PMID39943185
PMCPMC11816184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.