Evidence map›Paper›PMID 39943084›Full record

ArticleAnimals : an open access journal from MDPI2025

The Use of Antimicrobials in Animal Husbandry as a Potential Factor for the Increased Incidence of Colorectal Cancer: Food Safety and Kinetics in a Murine Model.

Rosa D'Ambrosio, Stefania Cavallo, Roberta Brunetti, Roberta Pellicanò, Emanuela Vaccaro, Giorgia Borriello, Rubina Paradiso, Francesco Paolo Serpe, Sara Lambiase, Francesca Bruzzese and 8 more

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Rosa D'AmbrosioIstituto Zooprofilattico Sperimentale del Mezzogiorno (IZSM), 80055 Portici, Italy.ORCID 0000-0001-6172-3446
Stefania CavalloIstituto Zooprofilattico Sperimentale del Mezzogiorno (IZSM), 80055 Portici, Italy.ORCID 0000-0001-5695-8005
Roberta BrunettiIstituto Zooprofilattico Sperimentale del Mezzogiorno (IZSM), 80055 Portici, Italy.ORCID 0000-0003-1597-9322
Roberta PellicanòIstituto Zooprofilattico Sperimentale del Mezzogiorno (IZSM), 80055 Portici, Italy.
Emanuela VaccaroDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, 80137 Napoli, Italy.ORCID 0009-0006-0380-0005
Giorgia BorrielloIstituto Zooprofilattico Sperimentale del Mezzogiorno (IZSM), 80055 Portici, Italy.ORCID 0000-0002-4672-6793
Rubina ParadisoIstituto Zooprofilattico Sperimentale del Mezzogiorno (IZSM), 80055 Portici, Italy.ORCID 0000-0002-8885-6086
Francesco Paolo SerpeIstituto Zooprofilattico Sperimentale del Mezzogiorno (IZSM), 80055 Portici, Italy.ORCID 0000-0001-7586-889X
Sara LambiaseIstituto Zooprofilattico Sperimentale del Mezzogiorno (IZSM), 80055 Portici, Italy.ORCID 0000-0003-4401-9865
Francesca BruzzeseExperimental Animal Unit, Istituto Nazionale Tumori-IRCCS-Fondazione "G. Pascale", 80131 Naples, Italy.
Giuseppe PalmaExperimental Animal Unit, Istituto Nazionale Tumori-IRCCS-Fondazione "G. Pascale", 80131 Naples, Italy.ORCID 0000-0003-4385-5896
Domenica ReaLaboratory Medicine Unit, Istituto Nazionale Tumori- IRCCS- Fondazione "G. Pascale", 80131 Naples, Italy.
Antonio BarbieriASL Salerno UOC Laboratorio d'Analisi, Vallo della Lucania, 84078 Salerno, Italy.
Marianna D'AmoreIstituto Zooprofilattico Sperimentale del Mezzogiorno (IZSM), 80055 Portici, Italy.
Maria DimatteoIstituto Zooprofilattico Sperimentale del Mezzogiorno (IZSM), 80055 Portici, Italy.ORCID 0009-0000-7425-4589
Barbara Degli UbertiIstituto Zooprofilattico Sperimentale del Mezzogiorno (IZSM), 80055 Portici, Italy.
Orlando PacielloDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, 80137 Napoli, Italy.ORCID 0000-0003-3091-0905
Loredana BaldiIstituto Zooprofilattico Sperimentale del Mezzogiorno (IZSM), 80055 Portici, Italy.ORCID 0000-0003-3087-7148

Funding

This research was funded by the Italian Ministry of Health Research Project IZS ME 07-18 RC
6 · The paper itself

Abstract

The aim of this research was to investigate the effects of the prolonged use of the broad-spectrum antimicrobial widely used in animal husbandry. By means of a mouse model, a translational study was carried out on immunocompetent mice (with a complete immune system). This study highlighted the effect of antimicrobial residues taken in with food on the growth time of cancer and on alterations to the gut microbiota. This project considered the fight against antimicrobial resistance from a One Health perspectivethrough collaboration between human medicine and veterinary medicine. Regarding food safety, antimicrobial residues in products of animal origin are rarely detected; they therefore constitute a negligible factor in determining colorectal cancer.

Indexed as

antimicrobialscolorectal cancerfood safetyOne Health

Identifiers

PMID39943084
PMCPMC11815752

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.