Evidence map›Paper›PMID 39943020›Full record

ArticlePlants (Basel, Switzerland)2025

Cell-Penetrating Peptide-Mediated Delivery of Gene-Silencing Nucleic Acids to the Invasive Common Reed

Qing Ji, Kurt P Kowalski, Edward M Golenberg, Seung Ho Chung, Natalie D Barker, Wesley A Bickford, Ping Gong

Abstract read
In one paragraph

Article in Plants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qing JiBennett Aerospace, Inc., Raleigh, NC 27603, USA.
Kurt P KowalskiU.S. Geological Survey, Great Lakes Science Center, Ann Arbor, MI 48105, USA.ORCID 0000-0002-8424-4701
Edward M GolenbergDepartment of Biological Sciences, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0002-0048-4776
Seung Ho ChungEnvironmental Laboratory, U.S. Army Engineer Research and Development Center, Vicksburg, MS 39180, USA.ORCID 0000-0003-4108-8320
Natalie D BarkerEnvironmental Laboratory, U.S. Army Engineer Research and Development Center, Vicksburg, MS 39180, USA.
Wesley A BickfordU.S. Geological Survey, Great Lakes Science Center, Ann Arbor, MI 48105, USA.ORCID 0000-0001-7612-1325
Ping GongEnvironmental Laboratory, U.S. Army Engineer Research and Development Center, Vicksburg, MS 39180, USA.ORCID 0000-0002-4861-9924

Funding

Great Lakes Restoration Initiative Not available
6 · The paper itself

Abstract

As a popular tool for gene function characterization and gene therapy, RNA interference (RNAi)-based gene silencing has been increasingly explored for potential applications to control invasive species. At least two major hurdles exist when applying this approach to invasive plants: (1) the design and screening of species- and gene-specific biomacromolecules (i.e., gene-silencing agents or GSAs) made of DNA, RNA, or peptides that can suppress the expression of target genes efficiently, and (2) the delivery vehicle needed to penetrate plant cell walls and other physical barriers (e.g., leaf cuticles). In this study, we investigated the cell-penetrating peptide (CPP)-mediated delivery of multiple types of GSAs (e.g., double-stranded RNA (dsRNA), artificial microRNA (amiRNA), and antisense oligonucleotide (ASO)) to knock down a putative phytoene desaturase (

Indexed as

antisense oligonucleotide (ASO)artificial microRNA (amiRNA)cell-penetrating peptide (CPP)double-stranded RNA (dsRNA)gene deliverygene silencingPhragmites australisphytoene desaturase (PDS)RNA interference (RNAi)γ-zein-CADY

Identifiers

PMID39943020
PMCPMC11820330

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.