Evidence map›Paper›PMID 39942783›Full record

ArticleMolecules (Basel, Switzerland)2025

Isolation and Bioassay of Linear Veraguamides from a Marine Cyanobacterium (

Stacy-Ann J Parker, Andrea Hough, Thomas Wright, Neil Lax, Asef Faruk, Christian K Fofie, Rebekah D Simcik, Jane E Cavanaugh, Benedict J Kolber, Kevin J Tidgewell

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Stacy-Ann J ParkerGraduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA.
Andrea HoughGraduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA.
Thomas WrightGraduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA.ORCID 0009-0007-6324-7464
Neil LaxDepartment of Neuroscience, Thiel College, Greenville, PA 16125, USA.
Asef FarukGraduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA.
Christian K FofieDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX 75080, USA.
Rebekah D SimcikDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX 75080, USA.ORCID 0009-0007-6006-7273
Jane E CavanaughGraduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA.
Benedict J KolberDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX 75080, USA.ORCID 0000-0001-8665-1805
Kevin J TidgewellGraduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA.ORCID 0000-0002-0501-2604

Funding

Understanding the role of anti-apolipoprotein A-I antibodies in atherosclerotic cardiovascular diseaseP20GM130456 · NIGMS · UNIVERSITY OF KENTUCKY · PI M. Ashfaqul Alam · 2020 to 2026
$18.7M
TO AWARD THE BASE PERIOD FOR NIMH PSYCHOACTIVE DRUG SCREENING PROGRAM (PDSP). BASE POP: 08/30/2023-08/29/2024.75N95023C00021 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROTH, BRYAN · 2023 to 2025
$9.0M
ICBG: "Training, Conservation and Drug Discovery using Panamanian MicroorganismsU01TW006634 · FIC · SMITHSONIAN INSTITUTION · PI GERWICK, WILLIAM HENRY · 2003 to 2013
$7.8M
Planning Study for the Development of Sigma 2 ligands as AnalgesicsR61NS127271 · NINDS · UNIVERSITY OF KENTUCKY · PI KOLBER, BENEDICT J, TIDGEWELL, KEVIN JOSEPH · 2023 to 2023
$1.5M
Cyanobacterial Natural Products to Treat Comorbid Pain and DepressionR15AT008060 · NCCIH · DUQUESNE UNIVERSITY · PI KOLBER, BENEDICT J, TIDGEWELL, KEVIN JOSEPH · 2014 to 2019
$905k
FIC NIH HHS U01 TW006634NCCIH NIH HHS R15 AT008060NIDA NIH HHS 75N95023C00021NIGMS NIH HHS P20 GM130456NIH HHS 1P20GM130456-05A1NIH HHS 1R15AT008060-02S1NIH HHS 1R61NS127271-01A1NINDS NIH HHS R61 NS127271
6 · The paper itself

Abstract

Marine cyanobacteria have gained momentum in recent years as a source of novel bioactive small molecules. This paper describes the structure elucidation and pharmacological evaluation of two new (veraguamide O (

Indexed as

Antineoplastic AgentsCyanobacteriaBiological AssayCell Line, TumorHEK293 CellsHumansMCF-7 CellsMolecular StructurePhylogenyAntineoplastic Agentscyanobacteriasigma 2TMEM-97veraguamide

Identifiers

PMID39942783
PMCPMC11819893

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.