Evidence map›Paper›PMID 39942745›Full record

SynthesisMolecules (Basel, Switzerland)2025

Potential of the Nano-Encapsulation of Antioxidant Molecules in Wound Healing Applications: An Innovative Strategy to Enhance the Bio-Profile.

Supandeep Singh Hallan, Francesca Ferrara, Rita Cortesi, Maddalena Sguizzato

Abstract readSystematic Review
In one paragraph

Synthesis in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Supandeep Singh HallanDepartment of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda 151401, India.ORCID 0000-0002-2882-0719
Francesca FerraraDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy.ORCID 0000-0002-9096-0560
Rita CortesiDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy.ORCID 0000-0002-1060-2676
Maddalena SguizzatoDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, I-44121 Ferrara, Italy.ORCID 0000-0002-2100-2043

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Naturally available antioxidants offer remarkable medicinal applications in wound healing. However, the encapsulation of these phytoactive moieties into suitable nano-scale drug delivery systems has always been challenging due to their inherent characteristics, such as low molecular weight, poor aqueous solubility, and inadequate skin permeability. Here, we provide a systematic review focusing on the major obstacles hindering the development of various lipid and polymer-based drug transporters to carry these cargos to the targeted site. Additionally, this review covers the possibility of combining the effects of a polymer and a lipid within one system, which could increase the skin permeability threshold. Moreover, the lack of suitable physical characterization techniques and the challenges associated with scaling up the progression of these nano-carriers limit their utility in biomedical applications. In this context, consistent progressive approaches for addressing these shortcomings are introduced, and their prospects are discussed in detail.

Indexed as

AntioxidantsNanoparticlesWound HealingAnimalsDrug CarriersDrug Delivery SystemsHumansPolymersAntioxidantsDrug CarriersPolymerscolloidal carriersdrug delivery systemsethosomeslipid-based nanosystemsliposomesmolecular dynamicsnanostructured lipid carriersskin absorptionsmall angle X-Ray scatteringsolid lipid nanoparticles

Identifiers

PMID39942745
PMCPMC11820390

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.