Evidence map›Paper›PMID 39942704›Full record

ArticleMolecules (Basel, Switzerland)2025

Synthesis and Antimycobacterial Assays of Some New Ethambutol Analogs.

Rana Abdelaziz, Mthandazo Dube, Lea Mann, Adrian Richter, Dina Robaa, Norbert Reiling, Mohammad Abdel-Halim, Peter Imming

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rana AbdelazizInstitut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, 06120 Halle (Saale), Germany.
Mthandazo DubeInstitut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, 06120 Halle (Saale), Germany.ORCID 0000-0002-1043-0480
Lea MannInstitut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, 06120 Halle (Saale), Germany.
Adrian RichterInstitut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, 06120 Halle (Saale), Germany.ORCID 0000-0002-0062-7896
Dina RobaaInstitut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, 06120 Halle (Saale), Germany.
Norbert ReilingRG Microbial Interface Biology, Research Center Borstel, Leibniz Lung Center, Parkallee 1-40, 23845 Borstel, Germany.ORCID 0000-0001-6673-4291
Mohammad Abdel-HalimDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, German University in Cairo, Cairo 11835, Egypt.ORCID 0000-0003-1326-4219
Peter ImmingInstitut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, 06120 Halle (Saale), Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ethambutol (EMB) is a first-line anti-tuberculosis drug that is also considered in treatment regimens for infections caused by non-tuberculous mycobacteria (NTM). EMB targets the arabinosyl transferases EmbCAB, which are important for the synthesis of cell wall constituents. To further explore and narrow down the structural variability of EMB, we synthesized three series of new EMB analogs. We tested their activity against

Indexed as

Antitubercular AgentsEthambutolMicrobial Sensitivity TestsMolecular StructureMycobacterium smegmatisMycobacterium tuberculosisStructure-Activity RelationshipAntitubercular AgentsEthambutolethambutol (EMB)mycobacteriaMycobacterium tuberculosisnon-tuberculous mycobacteria (NTM)

Identifiers

PMID39942704
PMCPMC11820526

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.