ArticleMolecules (Basel, Switzerland)2025
Exploration of the Fusidic Acid Structure Activity Space for Antibiotic Activity.
Yoon-Suk Kang, Simone C Silva, Kenneth Smith, Krissty Sumida, Yuhan Wang, Lucius Chiaraviglio, Ramachandra Reddy Donthiri, Alhanouf Z Aljahdali, James E Kirby, George A O'Doherty
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Simone C SilvaDepartment of Chemistry, Northeastern University, Boston, MA 02115, USA.
Kenneth SmithDepartment of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
Krissty SumidaDepartment of Chemistry, Northeastern University, Boston, MA 02115, USA.
Yuhan WangDepartment of Chemistry, Northeastern University, Boston, MA 02115, USA.
Lucius ChiaraviglioDepartment of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.ORCID 0000-0002-2613-6614 Alhanouf Z AljahdaliDepartment of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
James E KirbyDepartment of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
Funding
De Novo Synthesis, and Functional and Structural Characterization of Novel Aminoglycoside Analogues to Bypass Resistance Mechanisms and Optimize SelectivityR01AI154860 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KIRBY, JAMES E, O'DOHERTY, GEORGE A · 2020 to 2023
$3.1MFusidic acid derivatization to enhance entry into Gram-negative pathogensR21AI146485 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KIRBY, JAMES E, O'DOHERTY, GEORGE A · 2019 to 2020
$475kMassachusetts Life Sciences Center (Novel Therapeutics Delivery GrantNIAID NIH HHS R01 AI154860NIAID NIH HHS R21 AI146485NIH HHS AI146485 and AI154860NSF CHE-2102649 and CHE- 2400110
6 · The paper itselfAbstract
Fusidic acid is a translation inhibitor with activity against major Gram-positive bacterial pathogens such as
Indexed as
Anti-Bacterial AgentsFusidic AcidGram-Positive BacteriaMicrobial Sensitivity TestsMolecular StructureStaphylococcus aureusStructure-Activity RelationshipAnti-Bacterial AgentsFusidic Acidantibiotic natural product antibioticfusidic acidstructure–activity relationship
Identifiers
PMID39942570
PMCPMC11820832
What OpenQuestion holds
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LicenceCC BY
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