Evidence map›Paper›PMID 39942566›Full record

ArticleMolecules (Basel, Switzerland)2025

Human Pharmacokinetic Profiling and Comparative Analysis of Mangiferin and Its Monosodium Derivative from

David Fuentes-Rios, Alvaro Sanchez-Rodriguez, Laura Lopez-Rios, Eduardo Garcia-Gonzalez, Miriam Martinez-Canton, Victor Galvan-Alvarez, Angel Gallego-Selles, Marcos Martin-Rincon, Jose A L Calbet, Tanausu Vega-Morales

Registry-linked trialAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07126717 (Confirmatory Study on the Acute Effects of Zynamite® S on Cognitive Function and Mood in University Students), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07126717 nacompletednot on this map

Confirmatory Study on the Acute Effects of Zynamite® S on Cognitive Function and Mood in University Students: a Randomized, Double-blind, Placebo-controlled Crossover Study

TypeinterventionalSponsorNektium Pharma SLRan2025 to 2025Enrolled88ConditionsCognitive Performance, MoodArmsPlacebo, Zynamite® S
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Acute Supplementation of Soluble Mango Leaf Extract (ZynamitePharmaceuticals (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

David Fuentes-RiosNektium Pharma SL, C/Las Mimosas 8, Polígono Industrial Arinaga, 35118 Las Palmas, Spain.
Alvaro Sanchez-RodriguezNektium Pharma SL, C/Las Mimosas 8, Polígono Industrial Arinaga, 35118 Las Palmas, Spain.
Laura Lopez-RiosNektium Pharma SL, C/Las Mimosas 8, Polígono Industrial Arinaga, 35118 Las Palmas, Spain.ORCID 0000-0002-9386-5593
Eduardo Garcia-GonzalezDepartment of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, 35017 Las Palmas de Gran Canaria, Spain.
Miriam Martinez-CantonDepartment of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, 35017 Las Palmas de Gran Canaria, Spain.
Victor Galvan-AlvarezDepartment of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, 35017 Las Palmas de Gran Canaria, Spain.ORCID 0000-0002-1272-3471
Angel Gallego-SellesDepartment of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, 35017 Las Palmas de Gran Canaria, Spain.ORCID 0000-0002-8068-9586
Marcos Martin-RinconDepartment of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, 35017 Las Palmas de Gran Canaria, Spain.ORCID 0000-0002-3685-2331
Jose A L CalbetDepartment of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, 35017 Las Palmas de Gran Canaria, Spain.ORCID 0000-0002-9215-6234
Tanausu Vega-MoralesNektium Pharma SL, C/Las Mimosas 8, Polígono Industrial Arinaga, 35118 Las Palmas, Spain.ORCID 0000-0002-3357-6028

Funding

Ministerio de Economía y Competitividad PID2021-125354OB-C21
6 · The paper itself

Abstract

Mangiferin, a glucosyl xanthone, is a plant metabolite with promising nootropic and ergogenic properties. However, its poor and inconsistent systemic bioavailability limits its therapeutic potential. Additionally, the pharmacokinetics of mangiferin from mango leaf extract formulations remain uncharacterized in humans. This study validated a UHPLC-MS/MS method and conducted a human pharmacokinetic study approved by an ethics committee. The bioavailability of mangiferin and its monosodium salt was assessed from two standardized mango leaf extracts: MLE60, standardized to 60% mangiferin but practically insoluble in water, and MLES, the water-soluble monosodium salt form, also standardized to 60%. Twelve participants (six females) received oral doses of each extract in a crossover design with a 7-day washout period. Plasma analysis showed significantly higher AUC and C

Indexed as

MangiferaPlant ExtractsXanthonesAdultBiological AvailabilityChromatography, High Pressure LiquidCross-Over StudiesFemaleHumansMaleSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationTandem Mass SpectrometryYoung AdultMangifera indica extractmangiferinPlant ExtractsXanthonesbioavailabilityliquid chromatographymangiferinmass spectrometrypharmacokineticsalification

Identifiers

PMID39942566
PMCPMC11820055

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.