Evidence map›Paper›PMID 39942540›Full record

ArticleMolecules (Basel, Switzerland)2025

Functional Plant-Based Beverage Fortified with Hazelnut Cuticle Polyphenols: Antioxidant and Phenolic Content Characterization.

Raffaele Conte, Fabrizia Sepe, Sabrina Margarucci, Ezia Costanzo, Orsolina Petillo, Gianfranco Peluso, Loredana Marcolongo, Anna Calarco

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Polyphenol-Loaded Liposomal Nanocarriers fromMolecules (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Raffaele ConteResearch Institute on Terrestrial Ecosystems (IRET), CNR, Via Pietro Castellino 111, 80131 Naples, Italy.ORCID 0000-0002-6266-4991
Fabrizia SepeResearch Institute on Terrestrial Ecosystems (IRET), CNR, Via Pietro Castellino 111, 80131 Naples, Italy.
Sabrina MargarucciResearch Institute on Terrestrial Ecosystems (IRET), CNR, Via Pietro Castellino 111, 80131 Naples, Italy.
Ezia CostanzoResearch Institute on Terrestrial Ecosystems (IRET), CNR, Via Pietro Castellino 111, 80131 Naples, Italy.
Orsolina PetilloResearch Institute on Terrestrial Ecosystems (IRET), CNR, Via Pietro Castellino 111, 80131 Naples, Italy.ORCID 0000-0002-4193-6660
Gianfranco PelusoResearch Institute on Terrestrial Ecosystems (IRET), CNR, Via Pietro Castellino 111, 80131 Naples, Italy.
Loredana MarcolongoResearch Institute on Terrestrial Ecosystems (IRET), CNR, Via Pietro Castellino 111, 80131 Naples, Italy.ORCID 0000-0002-9332-8384
Anna CalarcoResearch Institute on Terrestrial Ecosystems (IRET), CNR, Via Pietro Castellino 111, 80131 Naples, Italy.ORCID 0000-0002-1441-7662

Funding

Italian Ministry of Foreign Affairs and International Cooperation(MAECI) in the frame of the NANOARBO project BR22GR04MUR-PRIN-2022 P2022RZ8WMNational Biodiversity Future Center (NBFC) Project code CN_00000033
6 · The paper itself

Abstract

In recent decades, there has been growing interest in the fortification of food products with antioxidants and phenolics derived from plant by-products. The present study focused on the production of a plant-based beverage enriched with hazelnut cuticle extract to characterize its antioxidant content, phenolic profile, and organoleptic characteristics. Liquid chromatography-mass spectrometry (LC-MS) enabled the identification of key polyphenols in hazelnut cuticles, including catechin, epicatechin, and quercetin derivatives, guiding the selection of a biocompatible Natural Deep Eutectic Solvent (NADES) composed of choline chloride and lactic acid for efficient extraction. The obtained phytochemical profile of the extract revealed a high concentration of bioactive compounds, with a Total Phenolic Content of 160.88 ± 14.27 mg GAE/g and Antioxidant Power measured by DPPH of 5848.2 ± 11.3 μmol TE/g. The bioaccessibility of phenolics in the fortified hazelnut-based beverage was determined after in vitro digestion, reaching a value of 89.7%, indicating excellent release and stability during digestion. Organoleptic evaluation revealed high sensory acceptability, with aftertaste scoring 3.61 ± 0.4 respect the 3.94 ± 1.3 result of reference milk, on a 5-point scale. In conclusion, this study demonstrates the potential for sustainable valorization of hazelnut cuticles, through their incorporation as NADES extracts in plant-based milk, providing an innovative solution to reduce food waste while catering to consumer demand for nutritionally enriched and eco-friendly products.

Indexed as

AntioxidantsCorylusFood, FortifiedPhenolsPolyphenolsHumansPlant ExtractsAntioxidantsPhenolsPlant ExtractsPolyphenolsbioaccessibilityhazelnut cuticlesnatural deep eutectic solvents (NADESs)plant by-products

Identifiers

PMID39942540
PMCPMC11820487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.