A Novel Strategy for the Detection of Semicarbazide in Crustaceans by Modified QuEChERS Coupled with Hydrophilic Interaction Liquid Chromatography-Tandem Mass Spectrometry.

Siyuan Wu, Yang Feng, Shengjun Chen, Yongqiang Zhao, Chunsheng Li, Jianchao Deng, Di Wang

Abstract read

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Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Siyuan WuCollege of Food Science, Shanghai Ocean University, Shanghai 201306, China.

Yang FengKey Laboratory of Aquatic Product, Ministry of Agriculture and Rural Affairs, National R&D Center for Aquatic Product Processing, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510330, China.ORCID 0009-0006-2733-6067

Shengjun ChenCollege of Food Science, Shanghai Ocean University, Shanghai 201306, China.ORCID 0000-0003-0841-3857

Yongqiang ZhaoKey Laboratory of Aquatic Product, Ministry of Agriculture and Rural Affairs, National R&D Center for Aquatic Product Processing, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510330, China.ORCID 0000-0001-8729-9583

Chunsheng LiKey Laboratory of Aquatic Product, Ministry of Agriculture and Rural Affairs, National R&D Center for Aquatic Product Processing, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510330, China.ORCID 0000-0003-1479-6831

Jianchao DengKey Laboratory of Aquatic Product, Ministry of Agriculture and Rural Affairs, National R&D Center for Aquatic Product Processing, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510330, China.

Di WangKey Laboratory of Aquatic Product, Ministry of Agriculture and Rural Affairs, National R&D Center for Aquatic Product Processing, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510330, China.

Funding

Financial Fund of the Ministry of Agriculture and Rural Affairs, P.R China No.NFZX2024Guangdong Basic and Applied Basic Research Foundation No. 2022A1515110550Hainan Provincial Natural Science Foundation of China 324MS129National Natural Science Foundation of China 32072147,22404175Special Scientific Research Funds for Central Non-profit Institutes of the Chinese Academy of Fishery Sciences 2023TD74，2023TD78

6 · The paper itself

Abstract

Semicarbazide (SEM), a metabolite of nitrofurazone (NFZ), is widely used to detect the illegal application of NFZ in crustaceans. The conventional detection method involves chemical derivatization combined with reversed-phase liquid chromatography-tandem mass spectrometry (RPLC-MS/MS), which is both complex and time-consuming. To address this limitation, a more efficient approach was developed for SEM detection. This study introduces a modified QuEChERS pretreatment method coupled with hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC-MS/MS) for detecting SEM in crustaceans. The proposed method is simple, fast, and highly accurate, making it universally applicable for SEM detection in crustaceans. Additionally, the method was applied to investigate NFZ metabolism in

Indexed as

crustaceansHILIC-MS/MSkinetic modelMacrobrachium rosenbergiinitrofurazoneQuEChERSsemicarbazideshrimp

Identifiers

PMID39942134

DOI10.3390/foods14030541

PMCPMC11816364

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.