Evidence map›Paper›PMID 39942046›Full record

ArticleFoods (Basel, Switzerland)2025

Optimized Extraction Protocols for Bioactive Antioxidants from Commercial Seaweeds in Portugal: A Comparative Study of Techniques.

Francisca Santos, Cristina Soares, Stephanie L Morais, Cátia Neves, Clara Grosso, Maria João Ramalhosa, Mónica Vieira, Cristina Delerue-Matos, Valentina F Domingues

Abstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Francisca SantosREQUIMTE/LAQV, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto, Portugal.
Cristina SoaresREQUIMTE/LAQV, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto, Portugal.ORCID 0000-0003-0924-9681
Stephanie L MoraisREQUIMTE/LAQV, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto, Portugal.ORCID 0000-0002-0341-4511
Cátia NevesREQUIMTE/LAQV, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto, Portugal.
Clara GrossoREQUIMTE/LAQV, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto, Portugal.
Maria João RamalhosaREQUIMTE/LAQV, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto, Portugal.ORCID 0000-0002-1951-3557
Mónica VieiraRISE-Health, Center for Translational Health and Medical Biotechnology Research (TBIO), CQB, ESS, Polytechnic of Porto, R. Dr. António Bernardino de Almeida, 400, 4200-072 Porto, Portugal.ORCID 0000-0002-8687-4811
Cristina Delerue-MatosREQUIMTE/LAQV, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto, Portugal.ORCID 0000-0002-3924-776X
Valentina F DominguesREQUIMTE/LAQV, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto, Portugal.ORCID 0000-0003-3472-849X

Funding

Fundação para a Ciência e Tecnologia LA/P/0008/2020-DOI 10.54499/LA/P/0008/2020Fundação para a Ciência e Tecnologia UIDB/50006/2020-DOI 10.54499/UIDB/50006/2020Fundação para a Ciência e Tecnologia UIDP/50006/2020-DOI10.54499/UIDP/50006/2020NextGenerationEu C644915664-00000026
6 · The paper itself

Abstract

This study aimed to optimize the extraction conditions for a valuable source of antioxidants: seaweed. Therefore, ten seaweed samples were subjected to a solid-liquid extraction (SLE), where the extraction conditions (biomass (g): solvent (mL) ratio, temperature, and time) were optimized using response surface methodology (RSM). The seaweeds were also subjected to subcritical water extraction (SWE) (140 and 190 °C) and ultrasound-assisted extraction (UAE) (10 and 20 min). The antioxidant capacity of the extracts was determined through the ferric-reducing antioxidant power and the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid). The total phenolic content revealed the significance of temperature and biomass; solvent ratio parameters in the extraction process with higher conditions generally promoting the release of phenolic compounds. Furthermore, applying RSM allowed for the identification of optimal conditions and the establishment of predictive models that can be valuable in industrial-scale extraction processes. The antioxidant potency composite index (APCI) shows that SWE at 190 °C stands out, with

Indexed as

antioxidant capacitymacroalgaesolid–liquid extractionsubcritical water extractionultrasound-assisted extraction

Identifiers

PMID39942046
PMCPMC11816920

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.