Evidence map›Paper›PMID 39942014›Full record

ArticleFoods (Basel, Switzerland)2025

Fermentation of Whole-Wheat Using Different Combinations of Lactic Acid Bacteria and Yeast: Impact on In Vitro and Ex Vivo Antioxidant Activity.

Elena Tomassi, Nafiou Arouna, Milena Brasca, Tiziana Silvetti, Sabrina de Pascale, Antonio Dario Troise, Andrea Scaloni, Laura Pucci

Abstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Effects of Sequential Fermentation withFoods (Basel, Switzerland) · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elena TomassiInstitute of Agricultural Biology and Biotechnology, National Research Council, 56124 Pisa, Italy.ORCID 0009-0006-4151-8000
Nafiou ArounaDepartment of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy.ORCID 0000-0002-2231-9990
Milena BrascaInstitute of Sciences of Food Production (ISPA), Italian National Research Council, 20133 Milan, Italy.ORCID 0000-0002-8821-0787
Tiziana SilvettiInstitute of Sciences of Food Production (ISPA), Italian National Research Council, 20133 Milan, Italy.ORCID 0000-0003-2205-2867
Sabrina de PascaleInstitute for the Animal Production System in the Mediterranean Environment, National Research Council, 80055 Portici, Italy.ORCID 0000-0001-9249-7058
Antonio Dario TroiseInstitute for the Animal Production System in the Mediterranean Environment, National Research Council, 80055 Portici, Italy.
Andrea ScaloniInstitute for the Animal Production System in the Mediterranean Environment, National Research Council, 80055 Portici, Italy.ORCID 0000-0001-9362-8515
Laura PucciInstitute of Agricultural Biology and Biotechnology, National Research Council, 56124 Pisa, Italy.

Funding

National Recovery and Resilience Plan, mission 4, component 2, investment 1.3, call n. 341/2022 of Italian Ministry of University and Research funded by the European Union - NextGenerationEU for the project "ON Food" project PE00000003, concession decree n. 1550/2022, CUP B83C22004790001National Research Council (CNR) for the project NUTRAGE project FOE-2021 (DBA.AD005.225)
6 · The paper itself

Abstract

Cereals are rich in nutrients and bioactive compounds; however, many of these, such as polyphenols, are bound to the cell wall matrix, limiting their bioavailability. This study investigated the use of fermentation to enhance the bioavailability of functional compounds in whole-wheat flour. Given the impact of microbial species on fermentation outcomes, various combinations of lactic acid bacteria and yeast strains were examined. The polyphenol and flavonoid content of different fermented flours was analyzed. Additionally, the antioxidant capacity was assessed using in vitro assays (DPPH, ORAC, and FRAP) and an ex vivo test with human erythrocytes. Fermentation significantly enhanced the release of bioavailable phenolic compounds and flavonoids, with the most significant increases reaching up to 3.4-fold and 2.64-fold, respectively. In particular, the findings highlight the capacity of flour fermented with a combination of

Indexed as

antioxidantfermentationlactic acid bacteria co-culturesshort-chain fatty acidswhole-wheatyeast

Identifiers

PMID39942014
PMCPMC11816817

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.