Evidence map›Paper›PMID 39941817›Full record

ArticleCancers2025

TLR2-Bound Cancer-Secreted Hsp70 Induces MerTK-Mediated Immunosuppression and Tumorigenesis in Solid Tumors.

Ahmet Kaynak, Subrahmanya D Vallabhapurapu, Harold W Davis, Eric P Smith, Petr Muller, Borek Vojtesek, Robert S Franco, Wen-Hai Shao, Xiaoyang Qi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Transboundary and emerging diseases · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ahmet KaynakDivision of Hematology & Oncology, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.ORCID 0000-0001-6551-1125
Subrahmanya D VallabhapurapuDivision of Hematology & Oncology, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Harold W DavisDivision of Hematology & Oncology, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Eric P SmithDivision of Hematology & Oncology, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.ORCID 0000-0002-9606-0109
Petr MullerMasaryk Memorial Cancer Institute, Research Centre for Applied Molecular Oncology, Zluty Kopec 7, 656 53 Brno, Czech Republic.ORCID 0000-0002-8404-4494
Borek VojtesekMasaryk Memorial Cancer Institute, Research Centre for Applied Molecular Oncology, Zluty Kopec 7, 656 53 Brno, Czech Republic.ORCID 0000-0001-6194-3705
Robert S FrancoDivision of Hematology & Oncology, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Wen-Hai ShaoDivision of Rheumatology, Allergy & Immunology, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.ORCID 0000-0002-4397-0539
Xiaoyang QiDivision of Hematology & Oncology, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.ORCID 0000-0001-5363-1760

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
Acidic Phospholipid-Selective Treatment for NeuroblastomaR01CA158372 · NCI · UNIVERSITY OF CINCINNATI · PI QI, XIAOYANG · 2011 to 2015
$1.6M
Axl receptor tyrosine kinase, a potential therapeutic target in glomerulonephritisR01DK116789 · NIDDK · UNIVERSITY OF CINCINNATI · PI SHAO, WEN-HAI · 2019 to 2021
$710k
NCATS NIH HHS UL1 TR001425NCI NIH HHS R01 CA158372NIDDK NIH HHS R01 DK116789
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cancerHsp70M2 macrophage polarizationMerTKphospho-Hsp70TLR2

Identifiers

PMID39941817
PMCPMC11815864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.