Evidence map›Paper›PMID 39941804›Full record

ArticleCancers2025

Tazemetostat, a Selective EZH2 Inhibitor, in Combination with Pembrolizumab for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: A Phase 1 Trial.

Peter J Oppelt, Sidharth V Puram, Jingxia Liu, Jessica C Ley, Douglas Adkins

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. The emerging landscape for next-generation HNSCC treatment.Trends in pharmacological sciences · 2026
    Review
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  3. Review
  4. Article
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Peter J OppeltDivision of Medical Oncology, Washington University School of Medicine, 660 South Euclid, Campus Box 8056, St Louis, MO 63110, USA.
Sidharth V PuramAlvin J. Siteman Cancer Center, St Louis, MO 63110, USA.ORCID 0000-0003-3543-889X
Jingxia LiuDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA.
Jessica C LeyDivision of Medical Oncology, Washington University School of Medicine, 660 South Euclid, Campus Box 8056, St Louis, MO 63110, USA.ORCID 0000-0001-5092-8884
Douglas AdkinsDivision of Medical Oncology, Washington University School of Medicine, 660 South Euclid, Campus Box 8056, St Louis, MO 63110, USA.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Epizyme (United States) NCT04624113NCI NIH HHS P30 CA091842
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

head and neck cancerpembrolizumabphase 1 trialrecurrent/metastatic squamous cell carcinomatazemetostat

Identifiers

PMID39941804
PMCPMC11816339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.