Evidence map›Paper›PMID 39941761›Full record

ArticleCancers2025

Timing Anti-PD-L1 Checkpoint Blockade Immunotherapy to Enhance Tumor Irradiation.

Steve Seung-Young Lee, Joanna Pagacz, Sera Averbek, David Scholten, Yue Liu, Stephen J Kron

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Timing matters: how mechanism-guided sequencing shapes the efficacy of radiotherapy-immunotherapy combinations : A systematic review.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Steve Seung-Young LeeDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, IL 60612, USA.ORCID 0000-0003-1349-3759
Joanna PagaczDepartment of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA.
Sera AverbekDepartment of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA.
David ScholtenDepartment of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA.
Yue LiuDepartment of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA.
Stephen J KronDepartment of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-1518-2436

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI CHIEN-MIN KAO · 1985 to 2026
$122.1M
Image-guided radiation-induced permeability (IGRIP) for IGDDR01CA199663 · NCI · UNIVERSITY OF CHICAGO · PI KRON, STEPHEN J., WEICHSELBAUM, RALPH R · 2015 to 2019
$2.5M
Systemic delivery of siRNA by Nanosac for checkpoint blockade immunotherapy of head and neck squamous cell cancerR01CA258737 · NCI · PURDUE UNIVERSITY · PI KRON, STEPHEN J., YEO, YOON · 2021 to 2024
$2.3M
Chemotherapy delivery with nanoparticles for targeted induction of immunogenic cell deathR01CA232419 · NCI · PURDUE UNIVERSITY · PI YEO, YOON · 2018 to 2022
$2.0M
Transparent Tumor Tomography (T3): Multi-Parameter 3D Imaging for Tumor ImmunotherapyR00EB022636 · NIBIB · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LEE, STEVE SEUNG-YOUNG · 2019 to 2021
$747k
Transparent Tumor Tomography (T3): Multi-Parameter 3D Imaging for Tumor ImmunotherapyK99EB022636 · NIBIB · UNIVERSITY OF CHICAGO · PI LEE, STEVE SEUNG-YOUNG · 2017 to 2018
$146k
NCI NIH HHS P30 CA014599NCI NIH HHS R01 CA199663NCI NIH HHS R01 CA232419NCI NIH HHS R01 CA258737NIBIB NIH HHS K99 EB022636NIBIB NIH HHS R00 EB022636
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

combination immunotherapyimmune checkpoint inhibitorradiotherapy/radioimmunotherapy

Identifiers

PMID39941761
PMCPMC11815760

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.