Evidence map›Paper›PMID 39941759›Full record

SynthesisCancers2025

Tumor Necrosis Factor-Alpha Inhibitor Use and Malignancy Risk: A Systematic Review and Patient Level Meta-Analysis.

Conor B Driscoll, Jordan M Rich, Dylan Isaacson, Joseph Nicolas, Yu Jiang, Xinlei Mi, Christopher Yang, Victoria Kocsuta, Regine Goh, Niti Patel and 10 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Conor B DriscollDepartment of Urology, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Suite 2300, Chicago, IL 60611, USA.ORCID 0000-0001-7730-6145
Jordan M RichDepartment of Urology, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Suite 2300, Chicago, IL 60611, USA.
Dylan IsaacsonDepartment of Urology, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Suite 2300, Chicago, IL 60611, USA.
Joseph NicolasDepartment of Urology, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Suite 2300, Chicago, IL 60611, USA.ORCID 0000-0002-3795-1120
Yu JiangDepartment of Epidemiology and Population Health, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA.ORCID 0000-0003-2914-8300
Xinlei MiDivision of Biostatistics, Department of Preventative Medicine, Northwestern University Feinberg School of Medicine, 680 N. Lake Shore Dr, Suite 1400, Chicago, IL 60611, USA.
Christopher YangDepartment of Urology, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Suite 2300, Chicago, IL 60611, USA.
Victoria KocsutaDepartment of Urology, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Suite 2300, Chicago, IL 60611, USA.
Regine GohDepartment of Urology, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Suite 2300, Chicago, IL 60611, USA.
Niti PatelDepartment of Medicine, Northwestern University Feinberg School of Medicine, 676 North St. Clair Street, Arkes Suite 2330, Chicago, IL 60611, USA.
Eric LiDepartment of Urology, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Suite 2300, Chicago, IL 60611, USA.
Mohammad Rashid SiddiquiDepartment of Urology, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Suite 2300, Chicago, IL 60611, USA.
Travis MeyersDepartment of Epidemiology and Biostatistics, University of California at San Francisco, 550 16th St., Floor 2, San Francisco, CA 94143, USA.
John S WitteDepartment of Epidemiology and Population Health, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA.
Linda KachuriDepartment of Epidemiology and Population Health, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA.
Hui ZhangDivision of Biostatistics, Department of Preventative Medicine, Northwestern University Feinberg School of Medicine, 680 N. Lake Shore Dr, Suite 1400, Chicago, IL 60611, USA.ORCID 0000-0001-6825-5649
Molly BeestrumGalter Health Sciences Library and Learning Center, Northwestern University, 303 E Chicago Ave #2-212, Chicago, IL 60611, USA.
Philip SilbermanDepartment of Information Technology, Northwestern University Feinberg School of Medicine, 710 N. Lake Shore Dr, Abbott Hall, 4th Floor, Chicago, IL 60611, USA.
Edward M SchaefferDepartment of Urology, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Suite 2300, Chicago, IL 60611, USA.
Shilajit D KunduDepartment of Urology, Northwestern University Feinberg School of Medicine, 676 North St Clair Street, Suite 2300, Chicago, IL 60611, USA.

Funding

Polsky Urologic Research Institute, Northwestern University N/A
6 · The paper itself

Abstract

Over the last two decades, tumor necrosis factor-alpha inhibitors (TNF-Is) have become standard therapies for chronic inflammatory disorders, with an ongoing expansion of indications and off-label applications [...].

Indexed as

adalimumabcancercertolizumabetanerceptgolimumabinfliximabmeta-analysisTNF-alpha

Identifiers

PMID39941759
PMCPMC11815771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.