Evidence map›Paper›PMID 39941713›Full record

ArticleCancers2025

The ELECTRA Trial: Approach to Contemporary Challenges in the Development and Implementation of Double-Blinded, Randomised, Controlled Clinical Trials in Low-Volume High-Complexity Surgical Oncology.

Sean Ewings, Nadia Peppa, Daniel Griffiths, Maria Hawkins, Claire Birch, Adly Naga, Georgina Parsons, Aymen Al-Shamkhani, Joanne Lord, Adrian C Bateman and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Prospective case-control cohort analysis of two-day/two-stage pelvic exenteration surgery: Safety, feasibility, acceptability and medium-term outcomes.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Sean EwingsCancer Research UK Southampton Clinical Trials Unit, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
Nadia PeppaCancer Research UK Southampton Clinical Trials Unit, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
Daniel GriffithsCancer Research UK Southampton Clinical Trials Unit, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
Maria HawkinsDepartment of Medical Physics and Biomedical Engineering, Faculty of Engineering Sciences, University College London, London WC1E 6BT, UK.
Claire BirchDepartment of Medical Physics, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
Adly NagaDepartment of Medical Physics, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.ORCID 0009-0002-3451-0546
Georgina ParsonsPatient and Public Representative, c/o Cancer Research UK Southampton Clinical Trials Unit, Southampton SO16 6YD, UK.
Aymen Al-ShamkhaniDepartment of Immunology, Cancer Sciences Division, University of Southampton, Southampton SO16 6YD, UK.
Joanne LordSouthampton Health Technology Assessments Group, University of Southampton, Southampton SO17 1BJ, UK.
Adrian C BatemanDepartment of Pathology, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.ORCID 0000-0003-2222-4104
Andrew BatemanDepartment of Clinical Oncology, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
Charlotte LaneDepartment of Radiology, University Hospital Southampton, Southampton SO16 6YD, UK.
Kelly CozensSouthampton Complex Cancer and Exenteration Team, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.ORCID 0000-0001-9592-9100
Gareth GriffithsCancer Research UK Southampton Clinical Trials Unit, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.ORCID 0000-0002-9579-8021
Simon J CrabbCancer Research UK Southampton Clinical Trials Unit, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.ORCID 0000-0003-3521-9064
Charles WestSouthampton Complex Cancer and Exenteration Team, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
Hideaki YanoSouthampton Complex Cancer and Exenteration Team, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
Malcolm A WestSouthampton Complex Cancer and Exenteration Team, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.ORCID 0000-0002-0345-5356
Alexander H MirnezamiSouthampton Complex Cancer and Exenteration Team, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.ORCID 0000-0002-6199-8332

Funding

Cancer Research UK CRCET\100006
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

intraoperative electron beam radiotherapylocally advanced rectal cancerlocally recurrent rectal cancersurgical randomised blinded trial

Identifiers

PMID39941713
PMCPMC11816246

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.