Evidence map›Paper›PMID 39941136›Full record

ArticleInternational journal of molecular sciences2025

CITE-Seq Analysis Reveals a Differential Natural Killer Cell

Sujit Silas Armstrong, Daniel G Chen, Sunil Kumar, James R Heath, Matthew J Feinstein, John R Greenland, Daniel R Calabrese, Lewis L Lanier, Klaus Ley, Avishai Shemesh

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sujit Silas ArmstrongLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Daniel G ChenInstitute of Systems Biology, University of Washington, Seattle, WA 98109, USA.ORCID 0000-0001-6660-6257
Sunil KumarImmunology Center of Georgia, Medical College of Georgia, Augusta, GA 30912, USA.ORCID 0000-0003-3139-114X
James R HeathInstitute of Systems Biology, University of Washington, Seattle, WA 98109, USA.
Matthew J FeinsteinDivision of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
John R GreenlandDepartment of Medicine, University of California, San Francisco, CA 94143, USA.ORCID 0000-0003-1422-8367
Daniel R CalabreseDepartment of Medicine, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-0596-3434
Lewis L LanierParker Institute for Cancer Immunotherapy, San Francisco, CA 94129, USA.ORCID 0000-0003-1308-3952
Klaus LeyImmunology Center of Georgia, Medical College of Georgia, Augusta, GA 30912, USA.
Avishai ShemeshParker Institute for Cancer Immunotherapy, San Francisco, CA 94129, USA.ORCID 0000-0002-6934-7155

Funding

Project 4: APOB-specific CD4 and CD8 T cells exacerbate atherosclerosisP01HL136275 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Catherine C Hedrick · 2017 to 2026
$25.5M
Vascular macrophages and T cells in atherosclerosisR35HL145241 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2019 to 2025
$5.9M
Telomere Dysfunction as a cause of Chronic Lung Allograft DysfunctionR01HL151552 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GREENLAND, JOHN · 2020 to 2024
$1.6M
BLRD VA IK2 BX005301CSRD VA I01 CX002011NHLBI NIH HHS P01 HL136275NHLBI NIH HHS R01 HL151552NHLBI NIH HHS R35 HL145241
6 · The paper itself

Abstract

Coronary artery disease (CAD) is linked to atherosclerosis plaque formation. In pro-inflammatory conditions, human Natural Killer (NK) cell frequencies in blood or plaque decrease; however, NK cells are underexplored in CAD pathogenesis, inflammatory mechanisms, and CAD comorbidities, such as human cytomegalovirus (HCMV) infection and diabetes. Analysis of PBMC CITE-seq data from sixty-one CAD patients revealed higher blood NK cell

Indexed as

Cardiovascular DiseasesCoronary Artery DiseaseCytomegalovirusCytomegalovirus InfectionsDiabetes MellitusKiller Cells, NaturalAgedFemaleHumansMaleMiddle Agedcardiovascular diseasecytomegalovirusdiabetesnatural killer cellsSPON2

Identifiers

PMID39941136
PMCPMC11818894

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.